Evidence map›Paper›PMID 29129682›Full record

ArticleStem cell reports2017

Spatial and Sex-Dependent Responses of Adult Endogenous Neural Stem Cells to Alcohol Consumption.

Erica L McGrath, Junling Gao, Yong-Fang Kuo, Tiffany J Dunn, Moniqua J Ray, Kelly T Dineley, Kathryn A Cunningham, Bhupendra S Kaphalia, Ping Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Erica L McGrathDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch at Galveston, Galveston 77555, USA; Institute for Translational Sciences, University of Texas Medical Branch at Galveston, Galveston 77555, USA; Center for Addiction Research, University of Texas Medical Branch at Galveston, Galveston 77555, USA; Department of Neurology, Johns Hopkins, Baltimore 21287, USA.
Junling GaoDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch at Galveston, Galveston 77555, USA.
Yong-Fang KuoDepartment of Preventive Medicine and Community Health, University of Texas Medical Branch at Galveston, Galveston 77555, USA.
Tiffany J DunnDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch at Galveston, Galveston 77555, USA.
Moniqua J RayDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch at Galveston, Galveston 77555, USA.
Kelly T DineleyCenter for Addiction Research, University of Texas Medical Branch at Galveston, Galveston 77555, USA; Department of Neurology, University of Texas Medical Branch at Galveston, Galveston 77555, USA.
Kathryn A CunninghamCenter for Addiction Research, University of Texas Medical Branch at Galveston, Galveston 77555, USA; Department of Pharmacology and Toxicology, University of Texas Medical Branch at Galveston, Galveston 77555, USA.
Bhupendra S KaphaliaDepartment of Pathology, University of Texas Medical Branch at Galveston, Galveston 77555, USA.
Ping WuDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch at Galveston, Galveston 77555, USA; Center for Addiction Research, University of Texas Medical Branch at Galveston, Galveston 77555, USA; Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China. Electronic address: piwu@utmb.edu.
The University of Texas Medical Branch at Galveston · USCapital Medical University · CNJohns Hopkins University · US

Funding

Translational Explorations in Substance Use DisordersT32DA007287 · NIDA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI Kathryn A. Cunningham, Jonathan Dean Hommel · 1994 to 2026
$4.7M
AMPK Signaling and Chronic Alcoholic PancreatitisR21AA024699 · NIAAA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI KAPHALIA, BHUPENDRA S · 2016 to 2017
$407k
NIAAA NIH HHS R21 AA024699NIDA NIH HHS T32 DA007287
6 · The paper itself

Abstract

Chronic alcohol abuse results in alcohol-related neurodegeneration, and critical gaps in our knowledge hinder therapeutic development. Neural stem cells (NSCs) are a subpopulation of cells within the adult brain that contribute to brain maintenance and recovery. While it is known that alcohol alters NSCs, little is known about how NSC response to alcohol is related to sex, brain region, and stage of differentiation. Understanding these relationships will aid in therapeutic development. Here, we used an inducible transgenic mouse model to track the stages of differentiation of adult endogenous NSCs and observed distinct NSC behaviors in three brain regions (subventricular zone, subgranular zone, and tanycyte layer) after long-term alcohol consumption. Particularly, chronic alcohol consumption profoundly affected the survival of NSCs in the subventricular zone and altered NSC differentiation in all three regions. Significant differences between male and female mice were further discovered.

Indexed as

Adult Stem CellsAlcohol DrinkingAlcoholsAnimalsBrain MappingCell DifferentiationDisease Models, AnimalFemaleLateral VentriclesMaleMiceMice, TransgenicNerve DegenerationNeural Stem CellsNeuronsAlcoholschronic alcoholneural stem cellneuronal differentiationsex differencessubgranular zonesubventricular zonetanycyte

Identifiers

PMID29129682
PMCPMC5785672
OpenAlexW2767298352

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.