Trial reportThe Journal of allergy and clinical immunology2018
Identification of atopic dermatitis subgroups in children from 2 longitudinal birth cohorts.
Trial report in The Journal of allergy and clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 5 syntheses or guidelines pooled it, 178 citations in OpenAlex.
- Machine learning-derived asthma and allergy trajectories in children: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.Nature communications · 2023Pooled it
- 12-month prevalence of atopic dermatitis in resource-rich countries: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Pooled it
- Pooled it
- Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT.Health technology assessment (Winchester, England) · 2024Trial
- Insights into adult atopic dermatitis heterogeneity derived from circulating biomarker profiling in patients with moderate-to-severe disease.Experimental dermatology · 2021Trial
- Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial.Lancet (London, England) · 2020Trial
- Phenotypes of atopic dermatitis and long-term body mass index trajectories.Pediatric research · 2026Article
- Multidisciplinary Delphi Consensus on management of children with moderate-severe atopic dermatitis.Italian journal of pediatrics · 2026Article
- Untangling the Complexity of Childhood Atopic Dermatitis: Phenotypes and Endotypes.Clinical reviews in allergy & immunology · 2026Review
- Developments in the Management Strategies for Allergy: Advances in Artificial Intelligence and Future Perspectives.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2026Review
- Incidence and Remission of Atopic Dermatitis in a German Birth Cohort.JAMA network open · 2025Observational
- Genetic predisposition for immunoglobulin E production explains atopic risk in children: Tohoku Medical Megabank cohort study.American journal of human genetics · 2025Article
- Eosinophil-derived neurotoxin levels can predict allergic disease development and atopic march in children.Clinical and experimental pediatrics · 2025Article
- The Janus face of Bifidobacterium in the development of atopic eczema: A role for compositional maturation.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- Atopic dermatitis and tobacco smoke exposure during childhood and adolescence.The journal of allergy and clinical immunology. Global · 2025Article
- Disagreement concerning atopic dermatitis subtypes between an English prospective cohort (ALSPAC) and linked electronic health records.Clinical and experimental dermatology · 2024Article
- Eczema in early childhood increases the risk of allergic multimorbidity.Clinical and translational allergy · 2024Article
- Defining disease severity in atopic dermatitis and psoriasis for the application to biomarker research: an interdisciplinary perspective.The British journal of dermatology · 2024Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundAtopic dermatitis (AD) is a prevalent disease with variable natural history. Longitudinal birth cohort studies provide an opportunity to define subgroups on the basis of disease trajectories, which may represent different genetic and environmental pathomechanisms.
objectivesWe sought to investigate the existence of distinct longitudinal phenotypes of AD and test whether these findings are reproducible in 2 independent cohorts.
methodsThe presence of AD was examined in 2 birth cohort studies including 9894 children from the United Kingdom (ALSPAC) and 3652 from the Netherlands (PIAMA). AD was defined by parental report of a typical itchy and/or flexural rash. Longitudinal latent class analysis was used to investigate patterns of AD from birth to the age of 11 to 16 years. We investigated associations with known AD risk factors, including FLG null mutations, 23 other established AD-genetic risk variants, and atopic comorbidity.
resultsSix latent classes were identified, representing subphenotypes of AD, with remarkable consistency between the 2 cohorts. The most prevalent class was early-onset-early-resolving AD, which was associated with male sex. Two classes of persistent disease were identified (early-onset-persistent and early-onset-late-resolving); these were most strongly associated with the AD-genetic risk score as well as personal and parental history of atopic disease. A yet unrecognized class of mid-onset-resolving AD, not associated with FLG mutations, but strongly associated with asthma, was identified.
conclusionsSix classes based on temporal trajectories of rash were consistently identified in 2 population-based cohorts. The differing risk factor profiles and diverse prognoses demonstrate the potential importance of a stratified medicine approach for AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.