ArticleClinical biomechanics (Bristol, Avon)2019
Aerosol deposition predictions in computed tomography-derived skeletons from severe asthmatics: A feasibility study.
Article in Clinical biomechanics (Bristol, Avon), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- Experimental Full-volume Airway Approximation for Assessing Breath-dependent Regional Aerosol Deposition.Device · 2024Article
- MultiscaleCurrent opinion in biomedical engineering · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe authors numerically investigated the correlation between airway skeletons of severe asthmatic human subjects and predicted aerosol deposition to shed light on the effect of environmental factors on asthma risk. We hypothesized that there are asthmatic subjects whose airway skeletal structure can expose the subject to a risk of higher local aerosol deposition compared to subjects with a more common/normal branching pattern.
methodsFrom a population of severe asthmatics studied at total lung capacity via computed tomography we randomly selected 8 subjects whose Forced Expiratory Volume in 1s, percent predicted fell below 45% predicted. To simulate aerosol motion in the human lungs, we employed in-house three-dimensional eddy-resolving computational fluid dynamics and particle tracking models utilizing 3 of the 8 severe asthmatic subjects. One of the 3 subjects was found to have a distinct, localized airway narrowing chosen for further investigation. In the simulation, we controlled flow rate and luminal area, i.e., Reynolds and Stokes numbers, in each branch of the computed tomography-derived airway skeletons.
findingsWe found a distinct enhancement of aerosol deposition associated with the narrowed branches of one subject even when the luminal area was numerically adjusted from its narrowed state to that of a non-asthmatic subject. The branching angle, freed of luminal narrowing persisted in demonstrating a marginally significant increase in local particle deposition compared with the subjects without the initial constriction.
interpretationThese results demonstrate the possibility that inherent airway structure may influence localized constriction found in severe asthmatics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.