SynthesisBiological psychiatry2018
Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium.
Synthesis in Biological psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The predictive value of polygenic risk scores for depression in gene-environment interaction studies: a systematic review.Translational psychiatry · 2026Pooled it
- Effects of adverse childhood experiences on behavior in adolescence: Insights from brain imaging and genetic risk.Developmental cognitive neuroscience · 2026Article
- Young adult self-harm: The role of victimisation and polygenic risk in a population-based longitudinal study.JCPP advances · 2026Article
- Joint Effects of Adverse Childhood Experiences and Genetic Burden of Depression on Multiple Depressive Symptoms.Stress and health : journal of the International Society for the Investigation of Stress · 2026Article
- The Role of Adverse Childhood Experiences in the Development of Major Depressive Disorder and Treatment-Resistant Depression.Child psychiatry and human development · 2026Review
- Cross-Ancestry Polygenic Prediction: Comparing Methods and Assessing Transferability Across Traits.Genetic epidemiology · 2026Article
- Polygenic scores in the study of gene-environment interplay and stress-related psychopathology.Frontiers in psychiatry · 2026Review
- Polygenic risk and trajectories of depressive symptoms in diverse adolescents: Gene-environment interplay with family conflict and parental acceptance.Development and psychopathology · 2025Article
- Polygenic Scores and Environmental Factors in Psychiatric Disorders: Gene-Environment Interaction Analyses Using the iPSYCH Study.Research square · 2025Article
- Childhood trauma and subclinical cin early adulthood: A genetically informative study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Neural effect of childhood maltreatment on neurovascular coupling in adolescent depression.European child & adolescent psychiatry · 2025Article
- Mechanisms of childhood trauma: an integrative review of a multimodal, transdiagnostic pathway.Neurobiology of stress · 2025Review
- Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Development and Evaluation of a Comprehensive Prediction Model for Incident Coronary Heart Disease Using Genetic, Social, and Lifestyle-Psychological Factors: A Prospective Analysis of the UK Biobank.Annals of internal medicine · 2025Article
- Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression.Molecular psychiatry · 2024Article
- Cross-ancestry genetic architecture and prediction for cholesterol traits.Human genetics · 2024Article
- Principles and methods for transferring polygenic risk scores across global populations.Nature reviews. Genetics · 2024Review
- Association of polygenic scores for depression and neuroticism with perceived stress in daily life during a long-lasting stress period.Genes, brain, and behavior · 2023Article
- A person-centered data analytic approach to dopaminergic polygenic moderation of child maltreatment exposure.Developmental psychobiology · 2023Article
- Family environment and polygenic risk in the bipolar high-risk context.JCPP advances · 2023Article
Corrections and comments
- Commented on by
- Erratum issuedErratum.2018
Authors and funding
29 authors.
Funding
Abstract
backgroundThe heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. This study aims to meta-analyze MDD-PRS × CT interaction results across these two and other cohorts, while applying more accurate PRSs based on a larger discovery sample.
methodsData were combined from 3024 MDD cases and 2741 control subjects from nine cohorts contributing to the MDD Working Group of the Psychiatric Genomics Consortium. MDD-PRS were based on a discovery sample of ∼110,000 independent individuals. CT was assessed as exposure to sexual or physical abuse during childhood. In a subset of 1957 cases and 2002 control subjects, a more detailed five-domain measure additionally included emotional abuse, physical neglect, and emotional neglect.
resultsMDD was associated with the MDD-PRS (odds ratio [OR] = 1.24, p = 3.6 × 10
conclusionsNo meta-analytic evidence for interaction between MDD-PRS and CT was found. This suggests that the previously reported interaction effects, although both statistically significant, can best be interpreted as chance findings. Further research is required, but this study suggests that the genetic heterogeneity of MDD is not attributable to genome-wide moderation of genetic effects by CT.
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