ReviewCurrent allergy and asthma reports2017
Pathomechanisms of Contact Sensitization.
Review in Current allergy and asthma reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- In Vitro Monitoring of Human T Cell Responses to Skin Sensitizing Chemicals-A Systematic Review.Cells · 2021Pooled it
- Article
- Article
- In Vitro Prediction of Skin-Sensitizing Potency Using the GARDskin Dose-Response Assay: A Simple Regression Approach.Toxics · 2024Article
- Patch testing in occupational dermatology: Practical aspects in relation to the conditions in Germany.Allergologie select · 2024Review
- Application of Luteolin in Neoplasms and Nonneoplastic Diseases.International journal of molecular sciences · 2023Review
- Consensus on the Key Characteristics of Immunotoxic Agents as a Basis for Hazard Identification.Environmental health perspectives · 2022Article
- Synchrotron-based characterization of arthroprosthetic CoCrMo particles in human bone marrow.Journal of materials science. Materials in medicine · 2022Article
- Transient injection site reaction to alirocumab during immune system activation: a case series.European heart journal. Case reports · 2022Article
- Frequencies and TCR Repertoires of Human 2,4,6-Trinitrobenzenesulfonic Acid-specific T Cells.Frontiers in toxicology · 2022Article
- Evaluation of skin sensitization based on interleukin-2 promoter activation in Jurkat cells.Biomedical reports · 2022Article
- Mechanisms of unconventional CD8 Tc2 lymphocyte induction in allergic contact dermatitis: Role of HFrontiers in immunology · 2022Article
- Adjuvants in fungicide formulations can be skin sensitizers and cause different types of cell stress responses.Toxicology reports · 2022Article
- Allergic contact dermatitis and associated allergic dermatoses: epidemiological, allergic, and immunological characteristics.Postepy dermatologii i alergologii · 2021Article
- Eosinophils in skin diseases.Seminars in immunopathology · 2021Review
- Contact dermatitis.Nature reviews. Disease primers · 2021Review
- Review
- Intricate Relationship Between Adaptive and Innate Immune System in Allergic Contact Dermatitis.The Yale journal of biology and medicine · 2020Review
- NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify.Pharmaceutics · 2020Review
- Art of prevention: The importance of feeding traditions.International journal of women's dermatology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contact sensitization is the initial process involved in the development of an allergic reaction to xenobiotic environmental substances. Here, we briefly describe the differences between irritant and allergic contact dermatitis. Then, we highlight the essential steps involved in the development of an ACD reaction, i.e., the protein binding of haptens, genetic factors influencing the penetration of sensitizers into the skin, the different mechanisms driving the initial development of an inflammatory cytokine micromilieu enabling the full maturation of dendritic cells, the role of pre- and pro-haptens, antigen presentation and T cell activation via MHC and CD1 molecules, dendritic cell (DC) migration, and potential LC contribution as well as the different T cell subsets involved in ACD. In addition, we discuss the latest publications regarding factors that might influence the sensitizing potential such as repeated sensitizer application, penetration enhancers, humidity of the skin, microbiota, Tregs, and phthalates. Last but not least, we briefly touch upon novel targets for drug development that might serve as treatment options for ACD.
Indexed as
Identifiers
29129023What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.