Evidence map›Paper›PMID 29129009›Full record

ArticleClinical rheumatology2018

IRAK2 is associated with susceptibility to rheumatoid arthritis.

Hana Ben Hassine, Rim Sghiri, Elyes Chabchoub, Asma Boumiza, Foued Slama, Khadija Baccouche, Zahid Shakoor, Adel Almogren, Christina Mariaselvam, Ryad Tamouza and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical rheumatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hana Ben HassineLaboratory of Immunology, Research Unit UR 807, Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia.
Rim SghiriLaboratory of Immunology, Research Unit UR 807, Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia. sghiririm@yahoo.com.
Elyes ChabchoubLaboratory of Immunology, Research Unit UR 807, Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia.
Asma BoumizaLaboratory of Immunology, Research Unit UR 807, Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia.
Foued SlamaLaboratory of Immunology, Research Unit UR 807, Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia.
Khadija BaccoucheDepartment of Rheumatology, Farhat Hached Hospital, Sousse, Tunisia.
Zahid ShakoorDepartment of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Adel AlmogrenDepartment of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Christina MariaselvamMondor Institute of Biomedical Research, U955, team 15, Henri Mondor Hospital, Créteil, France.
Ryad TamouzaMondor Institute of Biomedical Research, U955, team 15, Henri Mondor Hospital, Créteil, France.
Elyes BouajinaDepartment of Rheumatology, Farhat Hached Hospital, Sousse, Tunisia.
Ramzi ZemniLaboratory of Immunology, Research Unit UR 807, Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was performed to investigate the association of the single nucleotide polymorphisms of interleukin-1 receptor-associated kinase 2 (IRAK2) rs3844283 and rs708035 with rheumatoid arthritis (RA). IRAK2 rs3844283 and rs708035genotyping was determined by mutagenically separated PCR with specifically designed primers in a cohort of 222 (30 men, 192 women, mean age 49 years) adult RA patients and 224 matched controls. IRAK2 rs3844283 C allele was detected in 66% of RA patients and 74% of controls. The CC genotype was the most frequent genotype in both RA patients (45.5%) and the controls (56.3%). The G allele was found to be associated with RA susceptibility (OR = 1.47, 95% CI = 1.10-1.96, p = 0.008). The GG genotype was found to be associated with RA in the co-dominant and the dominant models (OR = 2.03, 95% CI = 1.08-3.81, p = 0.042 and OR = 1.54, 95% CI = 1.06-2.23, p = 0.023, respectively). IRAK2 rs708035 was found not to be in the Hardy-Weinberg equilibrium. The hyperfunctional IRAK2 rs708035 A allele was more frequent in RA patients than in controls (69.9 versus 62.2%, respectively, p = 0.015). Moreover, IRAK2 rs708035 and IRAK2 rs3844283 were in linkage disequilibrium and the GA haplotype was significantly more frequent in RA patients than in controls (p = 0.034). This study for the first time ever reports the association of IRAK2 rs3844283, IRAK2 rs708035, and the corresponding haplotypes with RA. Functional studies are recommended to elucidate the risk posed by the GA haplotype for the development of RA.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAdolescentAdultAgedAged, 80 and overAllelesArthritis, RheumatoidFemaleGene FrequencyGenotypeHaplotypesHumansInterleukin-1 Receptor-Associated KinasesMaleMiddle AgedInterleukin-1 Receptor-Associated KinasesIRAK3 protein, humanAnti-cyclic citrullinated peptide antibodiesC-reactive proteinDisease activity score 28Haplotype constructionIRAK2 rs3844283IRAK2 rs708035Joint erosionRheumatoid arthritisRheumatoid factorSharp/van der Heijde score

Identifiers

PMID29129009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.