ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2018
Comparison of olfactory and gustatory disorders in Alzheimer's disease.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Association Between Neurocognitive Disorders and Gustatory Dysfunction: A Systematic Review and Meta-Analysis.Neuropsychology review · 2024Pooled it
- Association of Odor Identification Ability With Amyloid-β and Tau Burden: A Systematic Review and Meta-Analysis.Frontiers in neuroscience · 2020Pooled it
- Evaluation of the effect of aroma oil as a bath salt on cognitive function.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2020Trial
- Effect of theFoods (Basel, Switzerland) · 2026Article
- Alzheimer's disease and cerebrovascular biomarkers in relation to odor identification in a naturalistic clinical cohort.Alzheimer's research & therapy · 2026Article
- Flavour perception in Alzheimer's disease: A systematic review of olfactory and gustatory assessment methods.JAR life · 2026Review
- Associations of combined smoking and drinking with subjective and objective olfactory dysfunction: A secondary dataset analysis of NHANES 2013-2014.Tobacco induced diseases · 2026Article
- Screening cognitive decline in older adults using umami hypogeusia and oral diadochokinesis: a cross-sectional study.BMC geriatrics · 2025Article
- Odor of Fatty Acids: Differences in Threshold and Perception Intensity Between Sexes.Foods (Basel, Switzerland) · 2025Article
- Association of impaired olfactory identification with prevalent mild cognitive impairment and regional brain atrophy: the Hisayama Study.Psychiatry and clinical neurosciences · 2025Article
- Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer's disease-associated proteopathology.Nature communications · 2025Article
- Insights into salt perception and cognitive impairment among middle-aged and older adults: a scoping review.BMC public health · 2025Article
- Aging-associated sensory decline and Alzheimer's disease.Molecular neurodegeneration · 2024Review
- Association of Olfactory and Gustatory Function with Memory among Community-Dwelling Independent Older Adults.Annals of geriatric medicine and research · 2024Article
- Subjective cognitive and olfactory impairments predict different prospective dementia outcomes.Chemical senses · 2024Article
- Association Between Olfactory Dysfunction and Cognitive Impairment in Dementia-Free Older Adults: A Prospective Cohort Study in Taiwan.Journal of Alzheimer's disease : JAD · 2023Article
- A potential biomarker of cognitive impairment: The olfactory dysfunction and its genes expression.Annals of clinical and translational neurology · 2022Article
- Article
- Olfactory function and discrimination ability in the elderly: a pilot study.The journal of physiological sciences : JPS · 2022Article
- Narrative Review of Sensory Changes as a Biomarker for Alzheimer's Disease.Biological research for nursing · 2021Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with Alzheimer's disease (AD) develop olfactory and gustatory disorders. However, the order of failure and relevance of the pathophysiology are unclear. We compared olfactory identification and whole mouth gustation in patients with AD to those with mild cognitive impairment (MCI) and to healthy controls (HC) and assessed correlations with pathophysiology. Patients with AD (n = 40), MCI (n = 34), and HC (n = 40) were recruited. We performed the Odor Stick Identification Test for Japanese (OSIT-J), gustatory test by the intraoral dropping method using taste solutions, Mini-Mental State Examination (MMSE), Alzheimer's Disease Assessment Scale-cognitive subscale Japanese version (ADAS-J cog), Touch Panel-type Dementia Assessment Scale (TDAS), and measurement of amyloid β (Aβ) 42 and phosphorylated tau (p-tau) 181 levels in cerebrospinal fluid (CSF). Patients with AD and MCI had lower OSIT-J scores than did the HC. The OSIT-J score was correlated with the MMSE, ADAS-J cog, TDAS, and Aβ42 results. There were no significant differences in the gustatory test scores among the three groups. The gustatory test score was only correlated with the MMSE, ADAS-J cog, and TDAS results. Olfactory function decreased in AD and MCI patients and was associated with CSF biomarker levels and cognitive disorders. The results suggest that olfactory function is impaired in early stage of AD. Gustatory function was not correlated with CSF biomarkers, which suggests that it may not be impaired in early stage of AD.
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