ArticleInfection and immunity1989
Effects of Histoplasma capsulatum on murine macrophage functions: inhibition of macrophage priming, oxidative burst, and antifungal activities.
Article in Infection and immunity, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Revisiting old friends: Developments in understanding Histoplasma capsulatum pathogenesis.Journal of microbiology (Seoul, Korea) · 2016Review
- Article
- Extracellular superoxide dismutase protects Histoplasma yeast cells from host-derived oxidative stress.PLoS pathogens · 2012Article
- Reverse genetics through random mutagenesis in Histoplasma capsulatum.BMC microbiology · 2009Article
- Killing of Paracoccidioides brasiliensis yeast cells by IFN-gamma and TNF-alpha activated murine peritoneal macrophages: evidence of H(2)O (2) and NO effector mechanisms.Mycopathologia · 2008Article
- A monoclonal antibody to Histoplasma capsulatum alters the intracellular fate of the fungus in murine macrophages.Eukaryotic cell · 2008Article
- The URA5 gene is necessary for histoplasma capsulatum growth during infection of mouse and human cells.Infection and immunity · 1999Article
- Inhibition of phagocytic activity by the N-acetyl-D-galactosamine-specific lectin from Amaranthus leucocarpus.Glycoconjugate journal · 1998Article
- Antihistoplasma effect of activated mouse splenic macrophages involves production of reactive nitrogen intermediates.Infection and immunity · 1994Article
- Acquired immunity in experimental murine aspergillosis is mediated by macrophages.Infection and immunity · 1993Article
- Gamma interferon cooperates with lipopolysaccharide to activate mouse splenic macrophages to an antihistoplasma state.Infection and immunity · 1993Article
- Article
- Colony-stimulating factors activate human macrophages to inhibit intracellular growth of Histoplasma capsulatum yeasts.Infection and immunity · 1992Article
- Alterations in murine macrophage arachidonic acid metabolism following ingestion of nonviable Histoplasma capsulatum.Infection and immunity · 1992Article
- Inhibition of murine macrophage protein kinase C activity by nonviable Histoplasma capsulatum.Infection and immunity · 1992Article
- Histoplasma variation and adaptive strategies for parasitism: new perspectives on histoplasmosis.Clinical microbiology reviews · 1991Review
- Inhibition of intracellular growth of Histoplasma capsulatum yeast cells by cytokine-activated human monocytes and macrophages.Infection and immunity · 1991Article
- In vivo activation of macrophage oxidative burst activity by cytokines and amphotericin B.Infection and immunity · 1990Article
- Deactivation of macrophage oxidative burst in vitro by different strains of Histoplasma capsulatum.MycopathologiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Histoplasma capsulatum yeast cells fail to trigger an oxidative burst response in normal murine macrophages. The results of this study, in which an in vitro assay of macrophage antifungal effects was used, extend these findings. During 18 h of incubation, unprimed elicited murine macrophages inhibited H. capsulatum growth only when macrophages were present in great excess. Gamma interferon (IFN-gamma)-primed macrophages showed enhanced fungal growth inhibition but a similar requirement for an excess of phagocytes. Macrophages containing heat-killed H. capsulatum exhibited diminished antifungal effects toward viable H. capsulatum and Saccharomyces cerevisiae cells. Parallel experiments showed no comparable effect of ingested latex particles on macrophage antifungal activity. Using chemiluminescence as a measure of the oxidative burst, we found that macrophages primed in vitro with IFN-gamma alone failed to exhibit a significant response to triggering by H. capsulatum yeast cells unless a second priming agent (tumor necrosis factor alpha or bacterial lipopolysaccharide) was added to IFN-gamma. Furthermore, macrophage priming with single agents was blocked by the prior ingestion of heat-killed H. capsulatum. These studies provide evidence that ingestion of H. capsulatum yeast cells can induce a prompt and enduring deactivation of murine macrophages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.