Evidence map›Paper›PMID 29128918›Full record

ArticleInternational journal of public health2018

Moderate physical activity reduces 10-year diabetes incidence: the mediating role of oxidative stress biomarkers.

Efi Koloverou, Konstantinos Tambalis, Demosthenes B Panagiotakos, Ekavi Georgousopoulou, Christina Chrysohoou, Ioannis Skoumas, Dimitrios Tousoulis, Christodoulos Stefanadis, Christos Pitsavos, ATTICA study group

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In one paragraph

Article in International journal of public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Efi KoloverouDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, St. El. Venizelou 70, Kallithea, Athens, Greece.
Konstantinos TambalisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, St. El. Venizelou 70, Kallithea, Athens, Greece.
Demosthenes B PanagiotakosDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, St. El. Venizelou 70, Kallithea, Athens, Greece. d.b.panagiotakos@usa.net.
Ekavi GeorgousopoulouDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, St. El. Venizelou 70, Kallithea, Athens, Greece.
Christina ChrysohoouFirst Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece.
Ioannis SkoumasFirst Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece.
Dimitrios TousoulisFirst Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece.
Christodoulos StefanadisFirst Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece.
Christos PitsavosFirst Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece.
ATTICA study group

Funding

Coca-Cola SA 10.9.2013Hellenic Atherosclerosis Society HAS 2004/2015Hellenic Cardiology Society HCS/2002
6 · The paper itself

Abstract

objectivesTo evaluate the effect of physical activity levels on 10-year diabetes incidence and investigate the potential mechanism.

methodsIn 2001-2002, a random sample of apparently healthy 3042 men and women (18-89 years) was selected to participate in the ATTICA study. Several socio-demographic, clinical and lifestyle characteristics were recorded. Physical activity level was recorded through a translated, validated, version of International Physical Activity Questionnaire (IPAQ); MET min/week was calculated and quartiles constructed. Diabetes diagnosis was defined according to the ADA criteria. During 2011-2012, a 10-year follow-up was performed.

resultsn = 191 cases were recorded, yielding an incidence of 12.9%. In multivariable analysis, moderate physical activity level (331-1484 MET min/week) was found to decrease 10-year diabetes incidence by 53% compared to very low physical activity (< 150 MET min/week) (OR = 0.47; 95% CI 0.24, 0.93). For high physical activity level (> 1484 MET min/week), the results were not significant. The antidiabetic effect was found to be mediated by oxidized LDL and total antioxidant capacity.

conclusionsThe current work revealed the significant beneficial role of moderate physical activity against diabetes development, potentially through attenuating oxidative stress.

Indexed as

AdultBiomarkersDiabetes Mellitus, Type 2ExerciseFemaleHumansIncidenceMaleMiddle AgedOxidative StressBiomarkersDiabetes incidenceOxidative stressPhysical activity

Identifiers

PMID29128918

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.