Evidence map›Paper›PMID 29128884›Full record

ArticleClinical and experimental nephrology2018

Effect of Npt2b deletion on intestinal and renal inorganic phosphate (Pi) handling.

Kayo Ikuta, Hiroko Segawa, Shohei Sasaki, Ai Hanazaki, Toru Fujii, Aoi Kushi, Yuka Kawabata, Ruri Kirino, Sumire Sasaki, Miwa Noguchi and 13 more

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical and experimental nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Review
  3. Phosphate intake, hyperphosphatemia, and kidney function.Pflugers Archiv : European journal of physiology · 2022
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Developmental Changes in Phosphate Homeostasis.Reviews of physiology, biochemistry and pharmacology · 2021
    Review
  10. Evidence of an intestinal phosphate transporter alternative to type IIb sodium-dependent phosphate transporter in rats with chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
    Article
  11. Kidney Disease Progression Does Not Decrease Intestinal Phosphorus Absorption in a Rat Model of Chronic Kidney Disease-Mineral Bone Disorder.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020
    Article
  12. Article
  13. Intestinal phosphate absorption: The paracellular pathway predominates?Experimental biology and medicine (Maywood, N.J.) · 2019
    Article
  14. The role of SLC34A2 in intestinal phosphate absorption and phosphate homeostasis.Pflugers Archiv : European journal of physiology · 2019
    Review
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 1 institution in 1 country.

Kayo IkutaDepartment of Molecular Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima, Tokushima, 770-8503, Japan.
Hiroko SegawaDepartment of Molecular Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima, Tokushima, 770-8503, Japan. segawa@tokushima-u.ac.jp.
Shohei SasakiDepartment of Molecular Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima, Tokushima, 770-8503, Japan.
Ai HanazakiDepartment of Molecular Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima, Tokushima, 770-8503, Japan.
Toru FujiiDepartment of Molecular Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima, Tokushima, 770-8503, Japan.
Aoi KushiDepartment of Molecular Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima, Tokushima, 770-8503, Japan.
Yuka KawabataDepartment of Molecular Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima, Tokushima, 770-8503, Japan.
Ruri KirinoDepartment of Molecular Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima, Tokushima, 770-8503, Japan.
Sumire SasakiDepartment of Molecular Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima, Tokushima, 770-8503, Japan.
Miwa NoguchiDepartment of Molecular Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima, Tokushima, 770-8503, Japan.
Ichiro KanekoDepartment of Molecular Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima, Tokushima, 770-8503, Japan.
Sawako TatsumiDepartment of Molecular Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima, Tokushima, 770-8503, Japan.
Otoya UedaFuji Gotemba Research Labs., Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka, Japan.
Naoko A WadaFuji Gotemba Research Labs., Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka, Japan.
Hiromi TateishiChugai Research Institute for Medical Science, Inc., 1-135, Komakado, Gotemba, Shizuoka, Japan.
Mami KakefudaChugai Research Institute for Medical Science, Inc., 1-135, Komakado, Gotemba, Shizuoka, Japan.
Yosuke KawaseChugai Research Institute for Medical Science, Inc., 1-135, Komakado, Gotemba, Shizuoka, Japan.
Shuichi OhtomoFuji Gotemba Research Labs., Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka, Japan.
Yasuhiro IchidaFuji Gotemba Research Labs., Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka, Japan.
Akira MaedaFuji Gotemba Research Labs., Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka, Japan.
Kou-Ichi JishageFuji Gotemba Research Labs., Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka, Japan.
Naoshi HoribaFuji Gotemba Research Labs., Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka, Japan.
Ken-Ichi MiyamotoDepartment of Molecular Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima, Tokushima, 770-8503, Japan.
Tokushima University · JP

Funding

Ministry of Education, Culture, Sports, Science and Technology (JP) 26293204Ministry of Education, Culture, Sports, Science and Technology (JP) 26461254
6 · The paper itself

Abstract

backgroundHyperphosphatemia is common in chronic kidney disease and is associated with morbidity and mortality. The intestinal Na

methodsIn the present study, we made tamoxifen-inducible Npt2b conditional knockout (CKO) mice to analyze systemic Pi metabolism, including intestinal Pi absorption.

resultsAlthough the Na

conclusionThese findings indicate that abnormal Pi metabolism may also be involved in tight junction molecules such as Cldns that are affected by Npt2b deficiency.

Indexed as

Intestinal AbsorptionAnimalsClaudinsKidneyMice, KnockoutMicrovilliPhosphatesSodium-Phosphate Cotransporter Proteins, Type IIbClaudinsNpt2b protein, mousePhosphatesSodium-Phosphate Cotransporter Proteins, Type IIbIntestineTranscellular transport–paracellular transport

Identifiers

PMID29128884
OpenAlexW2767856502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.