ArticleEuropean archives of psychiatry and clinical neuroscience2018
Neural substrate of unrelenting negative symptoms in schizophrenia: a longitudinal resting-state fMRI study.
Article in European archives of psychiatry and clinical neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Cerebellar-Prefrontal Connectivity Predicts Negative Symptom Severity Across the Psychosis Spectrum.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Imaging Biomarker Studies of Antipsychotic-Naïve First-Episode Schizophrenia in China: Progress and Future Directions.Schizophrenia bulletin · 2025Review
- Effects of long-term antipsychotic medication on brain instability in first-episode schizophrenia patients: a resting-state fMRI study.Frontiers in pharmacology · 2024Article
- Article
- Functional neurodevelopment of working memory in early-onset schizophrenia: A longitudinal FMRI study.Schizophrenia research. Cognition · 2022Article
- Contrasting Frontoparietal Network Connectivity in Antipsychotic Medication-Naive First-Episode Psychosis Patients Who Do and Do Not Display Features of the Deficit Syndrome.Schizophrenia bulletin · 2022Article
- Treatment Effect of Long-Term Antipsychotics on Default-Mode Network Dysfunction in Drug-Naïve Patients With First-Episode Schizophrenia: A Longitudinal Study.Frontiers in pharmacology · 2022Article
- Conceptual disorganization and redistribution of resting-state cortical hubs in untreated first-episode psychosis: A 7T study.NPJ schizophrenia · 2021Article
- Heterogeneity of Outcomes and Network Connectivity in Early-Stage Psychosis: A Longitudinal Study.Schizophrenia bulletin · 2021Article
- The Role of the Dorsolateral Prefrontal Cortex for Speech and Language Processing.Frontiers in human neuroscience · 2021Article
- Research Progress in Biological Studies of Schizophrenia in China in 2017.Shanghai archives of psychiatry · 2018Review
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Authors and funding
13 authors at 2 institutions in 4 countries.
Funding
Abstract
Developing a mechanistic insight into the specific brain processes that underpin improvement in negative symptoms can help us design novel chemical and physical treatments against these unrelenting symptoms. The aim of the present study is to explore the longitudinal changes in the brain's regional functional efficiency that accompany improvement in negative symptoms seen in first-episode patients with schizophrenia when treated with antipsychotic for 1 year. Forty-seven first-episode patients with schizophrenia were scanned at a drug-naive baseline state and followed up for 1 year to identify negative symptom responders (Rn) and non-responders (NRn). Fractional amplitude of low-frequency fluctuations (fALFF) and Granger analysis of effective connectivity (EC) were used to examine the different patterns of regional function and connectivity between Rn and NRn during the 1 year follow-up. Increase of fALFF in the left superior temporal gyrus (STG) and increase of EC from the left STG to the dorsolateral prefrontal cortex (DLPFC) was found in Rn compared to NRn. We further validated that the identified changes in fALFF/EC of STG occur specifically in relation to negative symptoms only (i.e., not pseudo-specific in relation to positive, extrapyramidal or depressive symptoms), and occur irrespective of arbitrary clinical categorization of treatment response. An increase in fALFF in the precuneus and the inferior parietal lobule, and a decrease in EC from the left STG to the occipital cortex, were also found at the 1 year follow-up irrespective of improvement in negative symptoms. Interventions that improve the functional efficiency of left STG and its prefrontal connectivity may show efficacy in alleviating negative symptoms in first-episode schizophrenia.
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