ArticleArchives of oral biology2018
Regionally variant collagen alignment correlates with viscoelastic properties of the disc of the human temporomandibular joint.
Article in Archives of oral biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Is the temporomandibular joint affected by rheumatoid arthritis? A comparative investigation with knee arthritis in an experimental rat model.Journal of anatomy · 2026Article
- Experimental and coupled quasi-linear viscoelastic biphasic modeling of regional and strain-rate dependent tensile behavior in the temporomandibular joint disc.Scientific reports · 2026Article
- 3D imaging and anisotropy mapping of the lamb disc for biomechanical and regenerative insights.Frontiers in physiology · 2026Article
- Nanofibrous scaffolds for bone and cartilage regeneration.Applied physics reviews · 2025Article
- Impact of storage techniques on ovine temporomandibular joint discs composition and physicochemical properties.Frontiers in bioengineering and biotechnology · 2025Article
- Bioactive scaffolds integrated with micro-precise spatiotemporal delivery andEngineered regeneration · 2025Article
- Tissue stiffness heterogeneity in the jaw and temporomandibular joint: its impact on tumor metabolism and considerations forFrontiers in physiology · 2025Review
- Characterization of the Temporomandibular Joint Disc Complex in the Yucatan Minipig.Tissue engineering. Part A · 2023Article
- A bioinspired and high-strengthed hydrogel for regeneration of perforated temporomandibular joint disc: Construction and pleiotropic immunomodulatory effects.Bioactive materials · 2023Article
- Oxo-M and 4-PPBP DeliveryFrontiers in bioengineering and biotechnology · 2022Article
- Biological Treatments for Temporomandibular Joint Disc Disorders: Strategies in Tissue Engineering.Biomolecules · 2021Review
- Effect of local anesthetics on viability and differentiation of various adult stem/progenitor cells.Stem cell research & therapy · 2020Article
- Temporomandibular joint imaging: current clinical applications, biochemical comparison with the intervertebral disc and knee meniscus, and opportunities for advancement.Skeletal radiology · 2020Review
- Temporomandibular Joint Condyle-Disc Morphometric Sexual Dimorphisms Independent of Skull Scaling.Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2019Article
- Effect of Measurement Technique on TMJ Mandibular Condyle and Articular Disc Morphometry: CBCT, MRI, and Physical Measurements.Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2019Article
- A Combination of Oxo-M and 4-PPBP as a potential regenerative therapeutics for tendon injury.Theranostics · 2019Article
- Considerations for translation of tissue engineered fibrocartilage from bench to bedside.Journal of biomechanical engineering · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo determine the regionally variant quality of collagen alignment in human TMJ discs and its statistical correlation with viscoelastic properties.
designFor quantitative analysis of the quality of collagen alignment, horizontal sections of human TMJ discs with Pricrosirius Red staining were imaged under circularly polarized microscopy. Mean angle and angular deviation of collagen fibers in each region were analyzed using a well-established automated image-processing for angular gradient. Instantaneous and relaxation moduli of each disc region were measured under stress-relaxation test both in tensile and compression. Then Spearman correlation analysis was performed between the angular deviation and the moduli. To understand the effect of glycosaminoglycans on the correlation, TMJ disc samples were treated by chondroitinase ABC (C-ABC).
resultsOur imaging processing analysis showed the region-variant direction of collagen alignment, consistently with previous findings. Interestingly, the quality of collagen alignment, not only the directions, was significantly different in between the regions. The angular deviation of fiber alignment in the anterior and intermediate regions were significantly smaller than the posterior region. Medial and lateral regions showed significantly bigger angular deviation than all the other regions. The regionally variant angular deviation values showed statistically significant correlation with the tensile instantaneous modulus and the relaxation modulus, partially dependent on C-ABC treatment.
conclusionOur findings suggest the region-variant degree of collagen fiber alignment is likely attributed to the heterogeneous viscoelastic properties of TMJ disc that may have significant implications in development of regenerative therapy for TMJ disc.
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