Evidence map›Paper›PMID 29128465›Full record

ArticleJournal of the American Academy of Dermatology2018

Psoriasis and the risk of diabetes: A prospective population-based cohort study.

Marilyn T Wan, Daniel B Shin, Rebecca A Hubbard, Megan H Noe, Nehal N Mehta, Joel M Gelfand

Abstract read
In one paragraph

Article in Journal of the American Academy of Dermatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 3 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 3 syntheses or guidelines pooled it, 132 citations in OpenAlex.

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  19. The effects of GLP-1RA on inflammatory skin diseases: A comprehensive review.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025
    Review
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Commented on by
    2018
5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Marilyn T WanDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Daniel B ShinDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Rebecca A HubbardCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Megan H NoeDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Nehal N MehtaNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Joel M GelfandDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Electronic address: Joel.Gelfand@uphs.upenn.edu.
University of Pennsylvania · USNational Heart Lung and Blood Institute · US

Funding

Psoriasis and the Risk of DiabetesK24AR064310 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI GELFAND, JOEL M · 2013 to 2017
$870k
NIAMS NIH HHS K24 AR064310
6 · The paper itself

Abstract

backgroundData evaluating the impact of objectively measured psoriasis severity on type 2 diabetes mellitus (T2DM) risk are lacking.

objectiveTo determine the risk for T2DM in patients with psoriasis compared with that in adults without psoriasis, stratified by categories of directly assessed body surface area (BSA) affected by psoriasis.

methodsA prospective, population-based, cohort study from the United Kingdom in which 8124 adults with psoriasis and 76,599 adults without psoriasis were followed prospectively for approximately 4 years.

resultsThere were 280 incident cases of diabetes in the psoriasis group (3.44%) and 1867 incident cases of diabetes in those without psoriasis (2.44%). After adjustment for age, sex and body mass index, the hazard ratios for development of incident diabetes were 1.21 (95% confidence interval [CI], 1.01-1.44), 1.01 (95% CI, 0.81-1.26), and 1.64 (95% CI, 1.23-2.18) in the groups with 2% or less of their BSA affected, 3% to 10% of their BSA affected, and 10% or more of their BSA affected compared with in the groups without psoriasis, respectively (P = .004 for trend). Worldwide, we estimate an additional 125,650 new diagnoses of T2DM per year in patients with psoriasis as compared with in those without psoriasis. LIMITATIONS: Relatively short-term follow-up and exclusion of prevalence cases, which may have masked associations in patients with less extensive psoriasis.

conclusionClinicians may measure BSA affected by psoriasis to target diabetes prevention efforts for patients with psoriasis.

Indexed as

AdultBody Surface AreaCase-Control StudiesDiabetes Mellitus, Type 2FemaleHumansIncidenceMaleMiddle AgedProspective StudiesPsoriasisRisk FactorsSeverity of Illness IndexUnited Kingdombody surface areacohort studydiabetesepidemiologypsoriasis

Identifiers

PMID29128465
PMCPMC5768452
OpenAlexW2768055286

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.