Trial reportJournal of immunological methods2018
Using sweat to measure cytokines in older adults compared to younger adults: A pilot study.
Trial report in Journal of immunological methods, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Measuring self-efficacy in U.S. older adults with chronic disease: a systematic review.Aging & mental health · 2025Pooled it
- Advances and Challenges in Wearable Sensors for Health Monitoring.ACS applied materials & interfaces · 2026Review
- Detection of cytokine release syndrome using wearables and cytokine profiling following CAR-T therapy for myeloma.JCI insight · 2026Observational
- Development of a noninvasive device and method for measuring immune parameters in skin disease.JID innovations : skin science from molecules to population health · 2026Article
- Multimodal Noninvasive Assessment of C-Reactive Protein for Systemic Inflammation in Adults: Cross-Sectional Study.JMIR formative research · 2025Article
- Mapping Multi-Modal Fatigue in Elite Soccer Through Sweat-Omics Perspectives: A Narrative Review.Biology · 2025Review
- Review
- Sleep efficiency in community-dwelling persons living with dementia: exploratory analysis using machine learning.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Observational
- Detection of Injury Biomarkers in Sweat of Collegiate Athletes Pre- and Post-Football Season: A Pilot Study.Neurotrauma reports · 2025Article
- Noninvasive, Multimodal Inflammatory Biomarker Discovery for Systemic Inflammation (NOVA Study): Protocol for a Cross-Sectional Study.JMIR research protocols · 2024Article
- Secretome Analysis Using Affinity Proteomics and Immunoassays: A Focus on Tumor Biology.Molecular & cellular proteomics : MCP · 2024Review
- Article
- Strengths-building through life purpose, self-care goal setting and social support: Study protocol for Caregiver Support.Contemporary clinical trials communications · 2022Article
- Wearable electrochemical biosensors to measure biomarkers with complex blood-to-sweat partition such as proteins and hormones.Mikrochimica acta · 2022Review
- High Social Coping Self-Efficacy Associated With Lower Sweat Interleukin-6 in Older Adults With Chronic Illness.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2022Article
- Ultrasensitive Detection of Dopamine, IL-6 and SARS-CoV-2 Proteins on Crumpled Graphene FET Biosensor.Advanced materials technologies · 2021Article
- Temporal profiling of cytokines in passively expressed sweat for detection of infection using wearable device.Bioengineering & translational medicine · 2021Article
- Point-of-care detection of cytokines in cytokine storm management and beyond: Significance and challenges.View (Beijing, China) · 2021Review
- A review of wearable biosensors for sweat analysis.Biomedical engineering letters · 2021Review
- Electrochemical sensing: A prognostic tool in the fight against COVID-19.Trends in analytical chemistry : TRAC · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND/
objectivesCurrent measures of cytokines involve urine, blood or saliva which have drawbacks including circadian rhythm variations and complicated collection methods. Sweat has been used to measure cytokines in young and middle-aged adults, but not older adults. We sought to determine the feasibility of using sweat to measure cytokines in older adults compared to younger adults.
designTwo visit cross-sectional pilot study stratified by age group.
settingIndependent living facility and Johns Hopkins University both in Maryland.
participants23 community-dwelling adults aged 65 and older and 26 adults aged 18-40 were included. Those with active cancer treatment or with a known terminal illness diagnosis were excluded. MEASUREMENTS: Sweat interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-α) were collected using a non-invasive sweat patch worn for 72h by each participant. Samples were measured with a single molecule array (SIMOA) technology for ultrasensitive, multiplexed detection of proteins.
results23 older adults and 26 younger adults with mean ages of 77±8.0years and 28±5.5years, respectively, completed the study. Both groups had high rates of compliance with patch wearing and removal. Higher concentrations of TNF-α, IL-6 and IL-10 were observed in older adults compared to younger adults, which remained significant after controlling for race, sex, body mass index, and chronic disease count (0.110±0.030 vs. 0.054±0.020pg/mL, 0.089±0.012 vs. 0.048±0.018pg/mL, and 0.124±0.029 vs. 0.067±0.025pg/mL, respectively).
conclusionThese results suggest that sweat patches are a feasible method to collect cytokine data from older adults. Preliminary group differences in cytokine measurement between older and younger groups correspond with current literature that cytokines increase with age, suggesting that sweat measurement using the sweat patch provides a new method of exploring the impact of inflammation on aging. Further research using sweat and the sweat patch is recommended.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.