ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
Structure analysis of capsid protein of Porcine circovirus type 2 from pigs with systemic disease.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Expression of recombinant Cap antigen of porcine circovirus type 2 in the chloroplast ofFrontiers in plant science · 2025Article
- Molecular evolution and genotype shift of Porcine circoviruses type 2 in Vietnam.Veterinary research communications · 2024Article
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- Identification of a conserved B-cell epitope on the capsid protein of porcine circovirus type 4.mSphere · 2024Article
- Development of a Gold Nanoparticle-Based ELISA for Detection of PCV2.Pathogens (Basel, Switzerland) · 2024Article
- Phylogenetic and Structural Analysis of Porcine Circovirus Type 2 from 2016 to 2021 in Jilin Province, China.Microorganisms · 2023Article
- Multiepitope Subunit Peptide-Based Nanovaccine against Porcine Circovirus Type 2 (PCV2) Elicited High Antibody Titers in Vaccinated Mice.Molecules (Basel, Switzerland) · 2023Article
- Colorimetric Kit for Rapid Porcine Circovirus 2 (PCV-2) Diagnosis.Pathogens (Basel, Switzerland) · 2022Article
- A bivalent porcine circovirus type 2 (PCV2), PCV2a-PCV2b, vaccine offers biologically superior protection compared to monovalent PCV2 vaccines.Veterinary research · 2022Article
- One Dose of a Novel Vaccine Containing Two Genotypes of Porcine Circovirus (PCV2a and PCV2b) andVaccines · 2021Article
- Article
- A Methodology for Porcine Circovirus 2 (PCV-2) Quantification Based on Gold Nanoparticles.Materials (Basel, Switzerland) · 2020Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Economic losses with high mortality rate associated with Porcine circovirus type 2 (PCV2) is reported worldwide. PCV2 commercial vaccine was introduced in 2006 in U.S. and in 2008 in Brazil. Although PCV2 vaccines have been widely used, cases of PCV2 systemic disease have been reported in the last years. Eleven nursery or fattening pigs suffering from PCV2 systemic disease were selected from eight PCV2-vaccinated farms with historical records of PCV2 systemic disease in Southern Brazil. PCV2 genomes were amplified and sequenced from lymph node samples of selected pigs. The comparison among the ORF2 amino acid sequences of PCV2 isolates revealed three amino acid substitutions in the positions F57I, N178S and A190T, respectively. Using molecular modeling, a structural model for the capsid protein of PCV2 was built. Afterwards, the mutated residues positions were identified in the model. The structural analysis of the mutated residues showed that the external residue 190 is close to an important predicted region for antibodies recognition. Therefore, changes in the viral protein conformation might lead to an inefficient antibody binding and this could be a relevant mechanism underlying the recent vaccine failures observed in swine farms in Brazil.
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