Evidence map›Paper›PMID 29128326›Full record

Trial reportSchizophrenia research2019

Cognitive remediation can improve negative symptoms and social functioning in first-episode schizophrenia: A randomized controlled trial.

Joseph Ventura, Kenneth L Subotnik, Denise Gretchen-Doorly, Laurie Casaus, Michael Boucher, Alice Medalia, Morris D Bell, Gerhard S Hellemann, Keith H Nuechterlein

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Schizophrenia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. EPA guidance on assessment of negative symptoms in schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2021
    Pooled it
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  9. Article
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  16. Developmental Manipulation-Induced Changes in Cognitive Functioning.Current topics in behavioral neurosciences · 2023
    Article
  17. Review
  18. Article
  19. Failed regeneration and inflammation in schizophrenia: two sides of the same coin?Journal of neural transmission (Vienna, Austria : 1996) · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joseph VenturaDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States. Electronic address: jventura@mednet.ucla.edu.
Kenneth L SubotnikDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States.
Denise Gretchen-DoorlyDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States.
Laurie CasausDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States.
Michael BoucherDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States.
Alice MedaliaDepartment of Psychiatry, Columbia University Medical Center, New York, New York.
Morris D BellDepartment of Psychiatry, Yale University, New Haven, Connecticut.
Gerhard S HellemannDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States.
Keith H NuechterleinDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States; Department of Psychology, University of California, Los Angeles, United States.

Funding

STRESS AND EMOTIONAL REACTIVITYP50MH066286 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YEE-BRADBURY, CINDY M. · 2003 to 2014
$18.6M
Enhancing Cognitive Training Through Exercise Following a First Schizophrenia EpisodeR01MH110544 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NUECHTERLEIN, KEITH H · 2016 to 2022
$7.3M
DEVELOPMENTAL PROCESSES IN SCHIZOPHRENIC DISORDERSR01MH037705 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NUECHTERLEIN, KEITH H · 1985 to 2010
$5.1M
TRANSMISSION OF VULNERABILITY FACTORS FOR SCHIZOPHRENIAR01MH049716 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NUECHTERLEIN, KEITH H · 1994 to 2006
$2.9M
Enhancing Cognitive Training through Exercise after a First Schizophrenia EpisodeR34MH102529 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NUECHTERLEIN, KEITH H · 2014 to 2015
$781k
NIMH NIH HHS P50 MH066286NIMH NIH HHS R01 MH037705NIMH NIH HHS R01 MH049716NIMH NIH HHS R01 MH110544NIMH NIH HHS R34 MH102529RRD VA IK6 RX002458
6 · The paper itself

Abstract

backgroundMeta-analyses have reported that the effects of cognitive remediation might go beyond improvement in cognition to include unexpected benefits for schizophrenia patients such as negative symptom reduction and improvements in functioning. In addition, some evidence indicated that these potentially beneficial effects are also present in the initial course of schizophrenia, but work in this area is still developing.

methodA RCT compared Cognitive Remediation (CR) to Healthy Behaviors Training (HBT) in 80 patients (78% male) with a mean age of 21.9years and mean education of 12.3years who had a first psychotic episode within two years of study entry. Participants were trained using CR programs or received HBT involving 50 sessions over 6months and then booster sessions over the next 6months. The SANS and BPRS were used to assess symptoms. The UCLA Social Attainment Survey assessed social functioning.

resultsUsing GLMM, improvements over 12months were found favoring CR for SANS Expressive Symptoms (p<0.01), which was composed of Affective Flattening (p<0.01) and Alogia (p=0.04), and for SANS Experiential Symptoms, composed of Avolition/Apathy (p=0.04) and Anhedonia/Asociality (p<0.01). CR was associated with improvements in social functioning (p=0.05) as compared to HBT.

conclusionsWe confirmed that the beneficial effects of CR appear to extend beyond cognition to improvements in negative symptoms and social functioning in early course schizophrenia patients. These results suggest that cognitive remediation might have an impact when the reduction of risk factors for chronicity is most critical for promoting recovery.

Indexed as

Cognitive RemediationOutcome Assessment, Health CareSocial BehaviorAdultAntipsychotic AgentsCombined Modality TherapyFemaleHealth BehaviorHumansMalePatient Education as TopicPsychotic DisordersSchizophreniaYoung AdultAntipsychotic AgentsCognitive remediationFirst episode schizophreniaNegative symptomsOutcomesRandomized controlled trialSocial functioning

Identifiers

PMID29128326
PMCPMC6589092

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.