ArticleInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology2018
Behavioral depression is associated with increased vagally mediated heart rate variability in adult female cynomolgus monkeys (Macaca fascicularis).
Article in International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Psychobiological Stress Regulation in Depressive Women Achieved Through Group Music Therapy: Results From the Randomised-Controlled Music Therapy for Depression Study.Stress and health : journal of the International Society for the Investigation of Stress · 2025Trial
- Differential effects of Mediterranean vs. Western diets on coronary atherosclerosis and peripheral artery transcriptomics.Frontiers in nutrition · 2025Article
- Recognising depression in non-human primates: a narrative review of reported signs of depression.PeerJ · 2025Review
- Diurnal variation of cardiac autonomic activity in adolescent non-suicidal self-injury.European archives of psychiatry and clinical neuroscience · 2024Article
- A sex-specific pathway linking early life maltreatment, vagal activity, and depressive symptoms.European journal of psychotraumatology · 2024Article
- Gender moderates the association between resting vagally mediated heart rate variability and attentional control.Frontiers in psychiatry · 2023Article
- Mediterranean Diet Reduces Social Isolation and Anxiety in Adult Female Nonhuman Primates.Nutrients · 2022Article
- Article
- Personal Resources and Organizational Outcomes: Sex as a Moderator of the Complex Relationships Between Self-Esteem, Heart Rate Variability, and Work-Related Exhaustion.Frontiers in neuroscience · 2021Article
- Gender Matters: Nonlinear Relationships Between Heart Rate Variability and Depression and Positive Affect.Frontiers in neuroscience · 2021Article
- Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases.Neuroscience bulletin · 2019Review
- Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
introductionDepressive symptoms (DS) in humans are associated with decreased resting state vagal activity, but sex seems to moderate this association. Recently, in human females DS have been associated with greater or similar cardiac vagal activity compared to men in both, clinical and non-clinical samples. A previously validated animal model of behavioral depression was used in the present study to investigate the association of DS and cardiac vagal activity in non-human primates.
methodsThe root mean square of successive differences between adjacent heart beats (RMSSD) was used as an indicator of vagally-mediated heart rate variability in 24h heart rate recordings collected via telemetry in 42 adult female cynomolgus monkeys (Macaca fascicularis). Hierarchical regression models were used to estimate differences in RMSSD comparing monkeys with and without DS. To capture circadian variation patterns of RMSSD, additional quadratic, cubic and quartic terms of hour were added.
resultsMonkeys showing behavioral DS had higher overall 24-h RMSSD. The interaction term of daytime with DS and polynomials of hour contributed significantly to the variance across models.
conclusionsThis is the first study investigating the association of DS and 24h cardiac vagal control in female non-human primates. Results replicate existing human studies showing higher cardiac vagal control in behavioral depressed vs. non-depressed female monkeys.
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