Evidence map›Paper›PMID 29128167›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2017

A prospective evaluation of hippocampal radiation dose volume effects and memory deficits following cranial irradiation.

Ting Martin Ma, Jimm Grimm, Riley McIntyre, Heather Anderson-Keightly, Lawrence R Kleinberg, Russell K Hales, Joseph Moore, Tracy Vannorsdall, Kristin J Redmond

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 79 citations in OpenAlex.

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  6. Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026
    Review
  7. Social information processing in survivors of pediatric brain tumors.Journal of cancer survivorship : research and practice · 2026
    Article
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  19. Progress in radiotherapy for small-cell lung cancer.Precision radiation oncology · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ting Martin MaDepartment of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, MD, United States.
Jimm GrimmDepartment of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, MD, United States.
Riley McIntyreDepartment of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, MD, United States.
Heather Anderson-KeightlyDepartment of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, MD, United States.
Lawrence R KleinbergDepartment of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, MD, United States.
Russell K HalesDepartment of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, MD, United States.
Joseph MooreDepartment of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, MD, United States.
Tracy VannorsdallDepartment of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Baltimore, MD, United States; Department of Neurology, The Johns Hopkins University, Baltimore, MD, United States.
Kristin J RedmondDepartment of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, MD, United States. Electronic address: kjanson3@jhmi.edu.
Johns Hopkins University · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
NCATS NIH HHS UL1 TR001079
6 · The paper itself

Abstract

background and purposeTo prospectively evaluate hippocampal radiation dose volume effects and memory decline following cranial irradiation. MATERIAL AND

methodsEffects of hippocampal radiation over a wide range of doses were investigated by combining data from three prospective studies. In one, adults with small cell lung cancer received hippocampal-avoidance prophylactic cranial irradiation. In the other two, adults with glioblastoma multiforme received neural progenitor cell sparing radiation or no sparing with extra dose delivered to subventricular zone. Memory was measured by the Hopkins Verbal Learning Test-Revised Delayed Recall (HVLT-R DR) at 6 months after radiation. Dose-volume histograms were generated and dose-response data were fitted to a nonlinear model.

resultsOf 60 patients enrolled, 30 were analyzable based on HVLT-R DR testing completion status, baseline HVLT-R DR and intracranial metastasis/recurrence or prior hippocampal resection status. We observed a dose-response of radiation to the hippocampus with regard to decline in HVLT-R DR. D50% of the bilateral hippocampi of 22.1 Gy is associated with 20% risk of decline.

conclusionsThis prospective study demonstrates an association between hippocampal dose volume effects and memory decline measured by HVLT-R DR over a wide dose range. These data support a potential benefit of hippocampal sparing and encourage continued trial enrollment.

Indexed as

AgedBrain NeoplasmsClinical Trials, Phase II as TopicCranial IrradiationFemaleGlioblastomaHippocampusHumansMaleMemoryMemory DisordersMiddle AgedNeoplasm Recurrence, LocalProspective StudiesRadiation DosageRadiation InjuriesDose responseHippocampusHopkins Verbal Learning Test-RevisedMemoryNeurocognitive functionRadiation therapy

Identifiers

PMID29128167
PMCPMC9161646
OpenAlexW2767788829

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.