Evidence map›Paper›PMID 29128142›Full record

ArticlePsychiatry research. Neuroimaging2018

Longitudinal effects of cognitive behavioral therapy for depression on the neural correlates of emotion regulation.

Harry Rubin-Falcone, Jochen Weber, Ronit Kishon, Kevin Ochsner, Lauren Delaparte, Bruce Doré, Francesca Zanderigo, Maria A Oquendo, J John Mann, Jeffrey M Miller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research. Neuroimaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Evidence Base Update for Questionnaires of Emotion Regulation and Reactivity for Children and Adolescents.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Pooled it
  4. Article
  5. Article
  6. Review
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  10. Review
  11. Article
  12. Thalamocortical Mechanisms for Nostalgia-Induced Analgesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  13. Case Report: Atonic PNES Capture in fMRI.Frontiers in neurology · 2022
    Article
  14. Article
  15. Article
  16. A Brain-Centric Model of Suicidal Behavior.The American journal of psychiatry · 2020
    Article
  17. Depression-related anterior cingulate prefrontal resting state connectivity normalizes following cognitive behavioral therapy.European psychiatry : the journal of the Association of European Psychiatrists · 2020
    Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Harry Rubin-FalconeDepartment of Psychiatry, Columbia University, New York, NY, USA; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
Jochen WeberDepartment of Psychology, Columbia University, New York, NY, USA.
Ronit KishonDepartment of Psychiatry, Columbia University, New York, NY, USA.
Kevin OchsnerDepartment of Psychology, Columbia University, New York, NY, USA.
Lauren DelaparteDepartment of Psychology, Stony Brook University, Stony Brook, NY, USA.
Bruce DoréAnnenberg School for Communication, University of Pennsylvania, Philadelphia, PA, USA.
Francesca ZanderigoDepartment of Psychiatry, Columbia University, New York, NY, USA; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
Maria A OquendoDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
J John MannDepartment of Psychiatry, Columbia University, New York, NY, USA; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
Jeffrey M MillerDepartment of Psychiatry, Columbia University, New York, NY, USA; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA. Electronic address: jm2233@cumc.columbia.edu.

Funding

The Neurochemistry of Cognitive Therapy: Predicting Treatment Outcome with PETK08MH085061 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MILLER, JEFFREY M · 2010 to 2014
$925k
NIMH NIH HHS K08 MH085061
6 · The paper itself

Abstract

Cognitive behavioral therapy (CBT) is effective for a substantial minority of patients suffering from major depressive disorder (MDD), but its mechanism of action at the neural level is not known. As core techniques of CBT seek to enhance emotion regulation, we scanned 31 MDD participants prior to 14 sessions of CBT using functional magnetic resonance imaging (fMRI) and a task in which participants engaged in a voluntary emotion regulation strategy while recalling negative autobiographical memories. Eighteen healthy controls were also scanned. Twenty-three MDD participants completed post-treatment fMRI scanning, and 12 healthy volunteers completed repeat scanning without intervention. Better treatment outcome was associated with longitudinal enhancement of the emotion regulation-dependent BOLD contrast within subgenual anterior cingulate, medial prefrontal cortex, and lingual gyrus. Baseline emotion regulation-dependent BOLD contrast did not predict treatment outcome or differ between MDD and control groups. CBT response may be mediated by enhanced downregulation of neural activity during emotion regulation; brain regions identified overlap with those found using a similar task in a normative sample, and include regions related to self-referential and emotion processing. Future studies should seek to determine specificity of this downregulation to CBT, and evaluate it as a treatment target in MDD.

Indexed as

EmotionsAdultBrain MappingCognitive Behavioral TherapyDepressionFemaleGyrus CinguliHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMemory, EpisodicMental RecallPrefrontal CortexTreatment OutcomeYoung AdultCBTCognitive behavioral therapyDepressionEmotion regulationFunctional MRIMDD

Identifiers

PMID29128142
PMCPMC5757508

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.