Evidence map›Paper›PMID 29127609›Full record

ArticleDigestive diseases and sciences2018

Gender-Based Differences in a Population-Based Cohort with Celiac Disease: More Alike than Unalike.

Claire L Jansson-Knodell, Katherine S King, Joseph J Larson, Carol T Van Dyke, Joseph A Murray, Alberto Rubio-Tapia

Open access · greenAbstract read
In one paragraph

Article in Digestive diseases and sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Menopause and gastrointestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  7. Article
  8. Observational
  9. Observational
  10. Article
  11. Review
  12. Sex- and gender-based medicine in pediatric nutrition.Italian journal of pediatrics · 2024
    Review
  13. Article
  14. Review
  15. Effectiveness of Hepatitis B Vaccination for Patients With Inflammatory Bowel and Celiac Disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023
    Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Claire L Jansson-KnodellDepartment of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Katherine S KingDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Joseph J LarsonDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Carol T Van DykeDivision of Gastroenterology and Hepatology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA.
Joseph A MurrayDivision of Gastroenterology and Hepatology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA.
Alberto Rubio-TapiaDivision of Gastroenterology and Hepatology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA. rubiotapia.alberto@mayo.edu.
Mayo Clinic · USMayo Clinic in Florida · USMayo Clinic in Arizona · USWinnMed · US

Funding

Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
EPIDEMIOLOGY OF CELIAC DISEASE--A POPULATION BASED STUDYR01DK057892 · NIDDK · MAYO CLINIC ROCHESTER · PI MURRAY, JOSEPH A · 2000 to 2010
$3.9M
NIA NIH HHS R01 AG034676NIDDK NIH HHS R01 DK057892NIH HHS NIH R01-DK57892
6 · The paper itself

Abstract

backgroundThere is a gap in research focused on gender-based differences in non-referral populations with celiac disease.

aimsThe aim of this study was to estimate those differences in a unique population-based cohort of patients with celiac disease with respect to (1) presenting symptoms, (2) associated autoimmune disorders, and (3) survival.

methodsClinical data were systematically abstracted from the electronic medical record of a population-based incident cohort of patients with celiac disease. Logistic regression was used to assess the strength of the association of presenting symptoms and gender. Survival differences between genders were evaluated with Cox regression.

resultsWe included 282 patients (females 65%, median age 39 years) diagnosed between 1990 and 2015. The female to male ratio was 1.85:1. Men and women presented similarly. Women were more likely to present with constipation (OR 2.33; 95% CI 1.06-5.12; p = 0.035). Anemia and abdominal distention or bloating were more frequently seen in women, but not on a statistically significant level. Overall autoimmune diseases were equally prevalent (31.6%) in males (30.2%) and females (32.2%) (p = 0.74). Hypothyroidism predominated in women. Age-adjusted survival was lower among men than women (HR 3.00; 95% CI 1.26-7.21, p = 0.014), but not more so than in the general population. Cancer was the most common cause of death, and there were two possible celiac disease-related deaths.

conclusionsThis study showed that men and women are more alike than unalike when it comes to celiac disease presentation and prevalence of concurrent autoimmune disease.

Indexed as

AdolescentAdultAgedAged, 80 and overCeliac DiseaseCohort StudiesFemaleHumansMaleMiddle AgedRisk FactorsSex FactorsYoung AdultAutoimmune conditionsGenderPopulationSexSprue

Identifiers

PMID29127609
PMCPMC5961510
OpenAlexW2767690643

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.