Evidence map›Paper›PMID 29127550›Full record

ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life2018

A Proposal of the Ur-proteome.

Miryam Palacios-Pérez, Fernando Andrade-Díaz, Marco V José

Abstract read
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In one paragraph

Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Miryam Palacios-PérezTheoretical Biology Group, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, C.P. 04510, Ciudad de México CDMX, Mexico.
Fernando Andrade-DíazTheoretical Biology Group, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, C.P. 04510, Ciudad de México CDMX, Mexico.
Marco V JoséTheoretical Biology Group, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, C.P. 04510, Ciudad de México CDMX, Mexico. marcojose@biomedicas.unam.mx.

Funding

CONACYT Mexico Fellowship 204546CONACYT Mexico Fellowship 694877DGAPA-UNAM PAPIIT IN224015
6 · The paper itself

Abstract

Herein we outline a plausible proteome, encoded by assuming a primeval RNY genetic code. We unveil the primeval phenotype by using only the RNA genotype; it means that we recovered the most ancestral proteome, mostly made of the 8 amino acids encoded by RNY triplets. By looking at those fragments, it is noticeable that they are positioned, not at catalytic sites, but in the cofactor binding sites. It implies that the stabilization of a molecule appeared long before its catalytic activity, and therefore the Ur-proteome comprised a set of proteins modules that corresponded to Cofactor Stabilizing Binding Sites (CSBSs), which we call the primitive bindome. With our method, we reconstructed the structures of the "first protein modules" that Sobolevsky and Trifonov (2006) found by using only RMSD. We also examine the probable cofactors that bound to them. We discuss the notion of CSBSs as the first proteins modules in progenotes in the context of several proposals about the primitive forms of life.

Indexed as

Evolution, MolecularOrigin of LifeAmino AcidsGenetic CodeProteomeRNAAmino AcidsProteomeRNACofactor stabilizing binding sitesLast universal common ancestorLigand bindingPrimeval RNY codeUr-proteome

Identifiers

PMID29127550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.