ReviewCell and tissue research2018
Identifying molecular mediators of environmentally enhanced neurogenesis.
Review in Cell and tissue research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Physical activity stimulates neurogenesis via sensory neuron activity in postembryonic zebrafish.iScience · 2026Article
- Exercise training promotes neurogenesis in the adult hippocampus with a particular focus on cell cycle regulation.Frontiers in sports and active living · 2026Review
- Emerging Pro-neurogenic Therapeutic Strategies for Neurodegenerative Diseases: A Review of Pre-clinical and Clinical Research.Molecular neurobiology · 2025Review
- Exercise training improves long-term memory in obese mice.Life metabolism · 2024Article
- Mechanisms underlying the effect of voluntary running on adult hippocampal neurogenesis.Hippocampus · 2023Review
- Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of fragile X syndrome.BMC medicine · 2022Article
- Environmental Enrichment Induces Meningeal Niche Remodeling through TrkB-Mediated Signaling.International journal of molecular sciences · 2021Article
- Environmental Enrichment Rescues Endocannabinoid-Dependent Synaptic Plasticity Lost in Young Adult Male Mice after Ethanol Exposure during Adolescence.Biomedicines · 2021Article
- Differential impact of stress and environmental enrichment on corticolimbic circuits.Pharmacology, biochemistry, and behavior · 2020Review
- Steps towards standardized quantification of adult neurogenesis.Nature communications · 2020Review
- Article
- Hippocampal deficits in neurodevelopmental disorders.Neurobiology of learning and memory · 2019Review
- Running-Activated Neural Stem Cells Enhance Subventricular Neurogenesis and Improve Olfactory Behavior in p21 Knockout Mice.Molecular neurobiology · 2019Article
- Environmental enrichment, new neurons and the neurobiology of individuality.Nature reviews. Neuroscience · 2019Review
- Conditioned media from AICAR-treated skeletal muscle cells increases neuronal differentiation of adult neural progenitor cells.Neuropharmacology · 2019Article
- Increased Synthesis of Chondroitin Sulfate Proteoglycan Promotes Adult Hippocampal Neurogenesis in Response to Enriched Environment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Regulation of Adult Neurogenesis by the Fragile X Family of RNA Binding Proteins.Brain plasticity (Amsterdam, Netherlands) · 2018Review
- Endocrine Crosstalk Between Skeletal Muscle and the Brain.Frontiers in neurology · 2018Review
- Neural stem cells: developmental mechanisms and disease modeling.Cell and tissue research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Adult hippocampal neurogenesis occurs throughout life and supports healthy brain functions. The production of new neurons decreases with age, and deficiencies in adult neurogenesis are associated with neurodevelopmental and degenerative disease. The rate of neurogenesis is dynamically sensitive to an individual's environmental conditions and experiences, and certain stimuli are known robustly to enhance neurogenesis in rodent models, including voluntary exercise, enriched environment, and electroconvulsive shock. In these models, information about an organism's environment and physiological state are relayed to neurogenic cell types within the hippocampus through a series of tissue and cellular interfaces, ultimately eliciting a neurogenic response from neural stem cells and newborn neurons. Therefore, an understanding of the way that novel genes and proteins act in specific cell types within this circuit-level context is of scientific and therapeutic value. Several well-studied neurotrophic factors have been implicated in environmentally enhanced neurogenesis. This review highlights recently discovered, novel molecular mediators of neurogenesis in response to environmental cues and summarizes the contribution of advanced, large-scale gene expression and function assessment technology to past, present, and future efforts aimed at elucidating cell-type-specific molecular mediators of environmentally enhanced neurogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.