Evidence map›Paper›PMID 29127344›Full record

ArticleScientific reports2017

Catabolic Effects of Human PTH (1-34) on Bone: Requirement of Monocyte Chemoattractant Protein-1 in Murine Model of Hyperparathyroidism.

Jawed A Siddiqui, Joshua Johnson, Carole Le Henaff, Claudine L Bitel, Joseph A Tamasi, Nicola C Partridge

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 41 citations in OpenAlex.

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  10. Gene Polymorphism Influencing Persistent Bone Resorption in Brown Tumor: A Case Series with Possible Pathogenesis and Potential Therapeutic Approach.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jawed A SiddiquiDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York, USA.
Joshua JohnsonDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York, USA.
Carole Le HenaffDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York, USA.
Claudine L BitelDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York, USA.
Joseph A TamasiBristol-Myers Squibb, Pennington, New Jersey, USA.
Nicola C PartridgeDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York, USA. ncp234@nyu.edu.
New York University · USBristol-Myers Squibb (United States) · US

Funding

Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5M
Nuclear Events in PTHR1 Action on BoneR01DK047420 · NIDDK · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Nicola C Partridge · 1994 to 2026
$8.0M
NCATS NIH HHS UL1 TR001445NIDDK NIH HHS R01 DK047420
6 · The paper itself

Abstract

The bone catabolic actions of parathyroid hormone (PTH) are seen in patients with hyperparathyroidism, or with infusion of PTH in rodents. We have previously shown that the chemokine, monocyte chemoattractant protein-1 (MCP-1), is a mediator of PTH's anabolic effects on bone. To determine its role in PTH's catabolic effects, we continuously infused female wild-type (WT) and MCP-1

Indexed as

HyperparathyroidismAnimalsBone ResorptionCancellous BoneChemokine CCL2Cortical BoneDisease Models, AnimalFemaleHumansMiceMice, KnockoutOsteoclastsParathyroid HormoneX-Ray MicrotomographyCcl2 protein, mouseChemokine CCL2Parathyroid HormonePTH protein, human

Identifiers

PMID29127344
PMCPMC5681546
OpenAlexW2767646448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.