ArticleScientific reports2017
Ectoine protects DNA from damage by ionizing radiation.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Fabrication of RADA32/Ngf_EE/MSCs composite hydrogel and its protective mechanism against radiation-induced ototoxicity.iScience · 2026Article
- Exploring the biotechnological potential of terrestrial hot spring microbiomes for COEnvironmental microbiome · 2026Article
- Coexpression of the Ectoine Biosynthetic Gene Cluster from Nocardiopsis dassonvillei NCIM 5124 in Escherichia coli by Using a Novel Strategy.Current microbiology · 2025Article
- Draft genome sequence and comparative genomic analysis of Halomonas salifodinae strain A2 isolated from the Zapotitlán Salinas Valley, Puebla, Mexico.Extremophiles : life under extreme conditions · 2025Article
- The Reduction of Skin Photodamage by the Ectoine-Thermus thermophilus Cofermentation Products.Journal of cosmetic dermatology · 2025Article
- The Influence of Ectoine on the Skin Parameters Damaged by a COMolecules (Basel, Switzerland) · 2025Article
- Exploring the microbial communities in coastal cenote and their hidden biotechnological potential.Microbial genomics · 2025Article
- Streptomyces sp. from desert soil as a biofactory for antioxidants with radical scavenging and iron chelating potential.BMC microbiology · 2024Article
- Multiple Functions of Compatible Solute Ectoine and Strategies for Constructing Overproducers for Biobased Production.Molecular biotechnology · 2024Review
- Ectoine Globally Hypomethylates DNA in Skin Cells and Suppresses Cancer Proliferation.Marine drugs · 2023Article
- Antioxidants in Sunscreens: Which and What For?Antioxidants (Basel, Switzerland) · 2023Article
- Bioactivity profiling of the extremolyte ectoine as a promising protectant and its heterologous production.3 Biotech · 2022Review
- Radiochemotheraphy-induced oral mucositis: Ectoin solution as a new treatment.Journal of clinical and experimental dentistry · 2022Article
- Visualization of DNA Damage and Protection by Atomic Force Microscopy in Liquid.International journal of molecular sciences · 2022Article
- Whole genome sequencing of the halophilic Halomonas qaidamensis XH36, a novel species strain with high ectoine production.Antonie van Leeuwenhoek · 2022Article
- Metabolic engineering ofFrontiers in microbiology · 2022Article
- Genome analysis of the salt-resistant Paludifilum halophilum DSM 102817World journal of microbiology & biotechnology · 2021Article
- Low-Energy Electron Damage to Condensed-Phase DNA and Its Constituents.International journal of molecular sciences · 2021Review
- New insights into hydroxyectoine synthesis and its transcriptional regulation in the broad-salt growing halophilic bacterium Chromohalobacter salexigens.Microbial biotechnology · 2021Article
- The saltern-derived3 Biotech · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ectoine plays an important role in protecting biomolecules and entire cells against environmental stressors such as salinity, freezing, drying and high temperatures. Recent studies revealed that ectoine also provides effective protection for human skin cells from damage caused by UV-A radiation. These protective properties make ectoine a valuable compound and it is applied as an active ingredient in numerous pharmaceutical devices and cosmetics. Interestingly, the underlying mechanism resulting in protecting cells from radiation is not yet fully understood. Here we present a study on ectoine and its protective influence on DNA during electron irradiation. Applying gel electrophoresis and atomic force microscopy, we demonstrate for the first time that ectoine prevents DNA strand breaks caused by ionizing electron radiation. The results presented here point to future applications of ectoine for instance in cancer radiation therapy.
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