Evidence map›Paper›PMID 29127333›Full record

ArticleScientific reports2017

A Light-Activated Antimicrobial Surface Is Active Against Bacterial, Viral and Fungal Organisms.

Tim Walker, Melisa Canales, Sacha Noimark, Kristopher Page, Ivan Parkin, Jane Faull, Manni Bhatti, Lena Ciric

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Tim WalkerHealthy Infrastructure Research Group, Department of Civil, Environmental & Geomatic Engineering, University College London, London, UK.
Melisa CanalesHealthy Infrastructure Research Group, Department of Civil, Environmental & Geomatic Engineering, University College London, London, UK.
Sacha NoimarkMaterials Chemistry Centre, Department of Chemistry, University College London, London, UK.
Kristopher PageMaterials Chemistry Centre, Department of Chemistry, University College London, London, UK.
Ivan ParkinMaterials Chemistry Centre, Department of Chemistry, University College London, London, UK.
Jane FaullDepartment of Biological Sciences, Birkbeck College, London, UK.
Manni BhattiHealthy Infrastructure Research Group, Department of Civil, Environmental & Geomatic Engineering, University College London, London, UK.
Lena CiricHealthy Infrastructure Research Group, Department of Civil, Environmental & Geomatic Engineering, University College London, London, UK. l.ciric@ucl.ac.uk.
University College London · GBBirkbeck, University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence has shown that environmental surfaces play an important role in the transmission of nosocomial pathogens. Deploying antimicrobial surfaces in hospital wards could reduce the role environmental surfaces play as reservoirs for pathogens. Herein we show a significant reduction in viable counts of Staphylococcus epidermidis, Saccharomyces cerevisiae, and MS2 Bacteriophage after light treatment of a medical grade silicone incorporating crystal violet, methylene blue and 2 nm gold nanoparticles. Furthermore, a migration assay demonstrated that in the presence of light, growth of the fungus-like organism Pythium ultimum and the filamentous fungus Botrytis cinerea was inhibited. Atomic Force Microscopy showed significant alterations to the surface of S. epidermidis, and electron microscopy showed cellular aggregates connected by discrete surface linkages. We have therefore demonstrated that the embedded surface has a broad antimicrobial activity under white light and that the surface treatment causes bacterial envelope damage and cell aggregation.

Indexed as

LightAnti-Infective AgentsFungiGentian VioletGoldLevivirusMetal NanoparticlesMethylene BlueStaphylococcus epidermidisSurface PropertiesAnti-Infective AgentsGentian VioletGoldMethylene Blue

Identifiers

PMID29127333
PMCPMC5681661
OpenAlexW2767971726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.