Evidence map›Paper›PMID 29127319›Full record

ArticleScientific reports2017

Mitochondrial gene polymorphism is associated with gut microbial communities in mice.

Misa Hirose, Axel Künstner, Paul Schilf, Annika Sünderhauf, Jan Rupp, Olaf Jöhren, Markus Schwaninger, Christian Sina, John F Baines, Saleh M Ibrahim

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 62 citations in OpenAlex.

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  19. The gut microbiome as a modulator of healthy ageing.Nature reviews. Gastroenterology & hepatology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Misa HiroseLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Axel KünstnerGroup for Medical Systems Biology, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Paul SchilfLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Annika SünderhaufInstitute of Nutritional Medicine, University of Lübeck, Lübeck, Germany.
Jan RuppDepartment of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.ORCID 0000-0001-8722-1233
Olaf JöhrenCenter of Brain, Behavior and Metabolism, University of Lübeck, Lübeck, Germany.
Markus SchwaningerInstitute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.ORCID 0000-0002-4510-9718
Christian SinaInstitute of Nutritional Medicine, University of Lübeck, Lübeck, Germany.
John F BainesMax Planck Institute for Evolutionary Biology, Evolutionary Genomics, Plön, Germany.
Saleh M IbrahimLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany. Saleh.Ibrahim@uksh.de.
University of Lübeck · DEEvolutionary Genomics (United States) · USMax Planck Institute for Evolutionary Biology · DEUniversity of Sharjah · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbial communities are key mediators of health and disease and have the capacity to drive the pathogenesis of diverse complex diseases including metabolic and chronic inflammatory diseases as well as aging. Host genetics is also a major determinant of disease phenotypes, whereby two different genomes play a role, the nuclear (nDNA)- and mitochondrial genome (mtDNA). We investigated the impact of mutations in mtDNA on the gut microbiota using conplastic mouse strains exhibiting distinct mutations in their mtDNA on an identical nDNA. Each of three strain tested harbors a distinct gut microbiota, ranging from differences at the phylum- to operational taxonomic units level. The C57BL/6J-mt

Indexed as

Genome, MitochondrialMutationPolymorphism, GeneticAnimalsDNA, MitochondrialGastrointestinal MicrobiomeMaleMiceMitochondriaMitochondrial Proton-Translocating ATPasesDNA, MitochondrialMitochondrial Proton-Translocating ATPasesmt-Atp8 protein, mouse

Identifiers

PMID29127319
PMCPMC5681637
OpenAlexW2767894491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.