Evidence map›Paper›PMID 29127278›Full record

ArticleNature communications2017

The North American bullfrog draft genome provides insight into hormonal regulation of long noncoding RNA.

S Austin Hammond, René L Warren, Benjamin P Vandervalk, Erdi Kucuk, Hamza Khan, Ewan A Gibb, Pawan Pandoh, Heather Kirk, Yongjun Zhao, Martin Jones and 11 more

Abstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Article
  2. Brain-derived ketone bodies can replace glucose to power neural function.bioRxiv : the preprint server for biology · 2026
    Article
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  6. Variations in Genetic Diversity of Invasive SpeciesAnimals : an open access journal from MDPI · 2024
    Article
  7. Plasticity in the Functional Properties of NMDA Receptors Improves Network Stability during Severe Energy Stress.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  8. Article
  9. Article
  10. Molecular profiling of COComparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

S Austin HammondCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 West 7th Ave - Suite 100, Vancouver, BC, Canada, V5Z 4S6.
René L WarrenCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 West 7th Ave - Suite 100, Vancouver, BC, Canada, V5Z 4S6.
Benjamin P VandervalkCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 West 7th Ave - Suite 100, Vancouver, BC, Canada, V5Z 4S6.
Erdi KucukCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 West 7th Ave - Suite 100, Vancouver, BC, Canada, V5Z 4S6.
Hamza KhanCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 West 7th Ave - Suite 100, Vancouver, BC, Canada, V5Z 4S6.
Ewan A GibbCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 West 7th Ave - Suite 100, Vancouver, BC, Canada, V5Z 4S6.
Pawan PandohCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 West 7th Ave - Suite 100, Vancouver, BC, Canada, V5Z 4S6.
Heather KirkCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 West 7th Ave - Suite 100, Vancouver, BC, Canada, V5Z 4S6.
Yongjun ZhaoCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 West 7th Ave - Suite 100, Vancouver, BC, Canada, V5Z 4S6.
Martin JonesCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 West 7th Ave - Suite 100, Vancouver, BC, Canada, V5Z 4S6.ORCID http://orcid.org/0000-0002-0905-2742
Andrew J MungallCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 West 7th Ave - Suite 100, Vancouver, BC, Canada, V5Z 4S6.ORCID http://orcid.org/0000-0002-0905-2742
Robin CoopeCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 West 7th Ave - Suite 100, Vancouver, BC, Canada, V5Z 4S6.
Stephen PleasanceCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 West 7th Ave - Suite 100, Vancouver, BC, Canada, V5Z 4S6.
Richard A MooreCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 West 7th Ave - Suite 100, Vancouver, BC, Canada, V5Z 4S6.
Robert A HoltCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 West 7th Ave - Suite 100, Vancouver, BC, Canada, V5Z 4S6.
Jessica M RoundDepartment of Biochemistry and Microbiology, University of Victoria, Petch Bldg Room 207, 3800 Finnerty Road, Victoria, BC, Canada, V8P 5C2.
Sara OhoraDepartment of Biochemistry and Microbiology, University of Victoria, Petch Bldg Room 207, 3800 Finnerty Road, Victoria, BC, Canada, V8P 5C2.
Branden V WalleDepartment of Biochemistry and Microbiology, University of Victoria, Petch Bldg Room 207, 3800 Finnerty Road, Victoria, BC, Canada, V8P 5C2.
Nik VeldhoenDepartment of Biochemistry and Microbiology, University of Victoria, Petch Bldg Room 207, 3800 Finnerty Road, Victoria, BC, Canada, V8P 5C2.
Caren C HelbingDepartment of Biochemistry and Microbiology, University of Victoria, Petch Bldg Room 207, 3800 Finnerty Road, Victoria, BC, Canada, V8P 5C2. chelbing@uvic.ca.
Inanc BirolCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 West 7th Ave - Suite 100, Vancouver, BC, Canada, V5Z 4S6. ibirol@bcgsc.ca.ORCID http://orcid.org/0000-0003-0950-7839

Funding

De Novo Assembly Tools: Research with Unbiased Engines - Renewal (DNA-TRUER)R01HG007182 · NHGRI · PROVINCIAL HEALTH SERVICES AUTHORITY · PI BIROL, INANC · 2014 to 2022
$1.9M
NHGRI NIH HHS R01 HG007182
6 · The paper itself

Abstract

Frogs play important ecological roles, and several species are important model organisms for scientific research. The globally distributed Ranidae (true frogs) are the largest frog family, and have substantial evolutionary distance from the model laboratory Xenopus frog species. Unfortunately, there are currently no genomic resources for the former, important group of amphibians. More widely applicable amphibian genomic data is urgently needed as more than two-thirds of known species are currently threatened or are undergoing population declines. We report a 5.8 Gbp (NG50 = 69 kbp) genome assembly of a representative North American bullfrog (Rana [Lithobates] catesbeiana). The genome contains over 22,000 predicted protein-coding genes and 6,223 candidate long noncoding RNAs (lncRNAs). RNA-Seq experiments show thyroid hormone causes widespread transcriptional change among protein-coding and putative lncRNA genes. This initial bullfrog draft genome will serve as a key resource with broad utility including amphibian research, developmental biology, and environmental research.

Indexed as

GenomeAnimalsComputational BiologyGenome, MitochondrialMaleMolecular Sequence AnnotationNorth AmericaPhylogenyRana catesbeianaRNA, Long NoncodingThyroid HormonesRNA, Long NoncodingThyroid Hormones

Identifiers

PMID29127278
PMCPMC5681567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.