ArticleNature communications2017
Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Lineage tracing from cellular heritage to disease destiny.Nature genetics · 2026Review
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- Multiplexed, image-based pooled screens in primary cells and tissues with PerturbView.Nature biotechnology · 2025Article
- Resolving tumor evolution: a phylogenetic approach.Journal of the National Cancer Center · 2024Review
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- Dissecting metastasis using preclinical models and methods.Nature reviews. Cancer · 2023Review
- Multidimensional Imaging of Breast Cancer.Cold Spring Harbor perspectives in medicine · 2023Review
- State-dependent evolutionary models reveal modes of solid tumour growth.Nature ecology & evolution · 2023Article
- Impact of crowding on the diversity of expanding populations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- In vivo 3D profiling of site-specific human cancer cell morphotypes in zebrafish.The Journal of cell biology · 2022Article
- Mastering the use of cellular barcoding to explore cancer heterogeneity.Nature reviews. Cancer · 2022Review
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- 3D imaging for driving cancer discovery.The EMBO journal · 2022Review
- Antagonism between killer yeast strains as an experimental model for biological nucleation dynamics.eLife · 2021Article
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- Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer.EMBO molecular medicine · 2021Article
- Spatial omics and multiplexed imaging to explore cancer biology.Nature methods · 2021Review
- Subversion of Niche-Signalling Pathways in Colorectal Cancer: What Makes and Breaks the Intestinal Stem Cell.Cancers · 2021Review
- 5-Hydroxymethylcytosine signature in circulating cell-free DNA as a potential diagnostic factor for early-stage colorectal cancer and precancerous adenoma.Molecular oncology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colon cancers are composed of phenotypically heterogeneous tumor cell subpopulations with variable expression of putative stem cell and differentiation antigens. While in normal colonic mucosa, clonal repopulation occurs along differentiation gradients from crypt base toward crypt apex, the clonal architecture of colon cancer and the relevance of tumor cell subpopulations for clonal outgrowth are poorly understood. Using a multicolor lineage tracing approach in colon cancer xenografts that reflect primary colon cancer architecture, we here demonstrate that clonal outgrowth is mainly driven by tumor cells located at the leading tumor edge with clonal axis formation toward the tumor center. While our findings are compatible with lineage outgrowth in a cancer stem cell model, they suggest that in colorectal cancer tumor cell position may be more important for clonal outgrowth than tumor cell phenotype.
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Registered trials
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