Evidence map›Paper›PMID 29127201›Full record

ArticleThe Journal of biological chemistry2017

Loss of the mucosal barrier alters the progenitor cell niche via Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling.

Liping Zhang, Bradley Turner, Katharina Ribbeck, Kelly G Ten Hagen

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Glycan-related genes and genetic disorders.Journal of human genetics · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. In vivo models of mucin biosynthesis and function.Advanced drug delivery reviews · 2022
    Review
  7. Article
  8. Epithelial Cell Polarity DuringFrontiers in cell and developmental biology · 2022
    Review
  9. Differential splicing of the lectin domain of anThe Journal of biological chemistry · 2020
    Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. The Possible Anti-Inflammatory Effect of Dehydrocostus Lactone on DSS-Induced Colitis in Mice.Evidence-based complementary and alternative medicine : eCAM · 2020
    Article
  16. Article
  17. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  18. O-Linked glycosylation in Drosophila melanogaster.Current opinion in structural biology · 2019
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Liping ZhangFrom the Developmental Glycobiology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892-4370 and.
Bradley Turnerthe Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Katharina Ribbeckthe Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Kelly G Ten HagenFrom the Developmental Glycobiology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892-4370 and Kelly.Tenhagen@nih.gov.ORCID 0000-0002-2057-8120
Massachusetts Institute of Technology · USNational Institutes of Health · US

Funding

Role of O-glycosylation in Animal DevelopmentZIADE000713 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI TEN HAGEN, KELLY G · 2009 to 2025
$30.6M
TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LEVINE, STUART S · 1985 to 2020
$25.6M
Mucin Glycans in the Regulation of Microbial VirulenceR01EB017755 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI RIBBECK, KATHARINA · 2013 to 2022
$3.6M
Role of O-glycosylation in Animal DevelopmentZ01DE000713 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI TEN HAGEN, KELLY G · 2006 to 2008
$2.0M
Intramural NIH HHS Z01 DE000713NIBIB NIH HHS R01 EB017755NIEHS NIH HHS P30 ES002109
6 · The paper itself

Abstract

The mucous barrier of our digestive tract is the first line of defense against pathogens and damage. Disruptions in this barrier are associated with diseases such as Crohn's disease, colitis, and colon cancer, but mechanistic insights into these processes and diseases are limited. We have previously shown that loss of a conserved

Indexed as

AnimalsCell DifferentiationCytokinesDrosophilaDrosophila ProteinsIntestinal MucosaJanus KinasesN-AcetylgalactosaminyltransferasesParacrine CommunicationSignal TransductionSTAT Transcription FactorsStem Cell NicheStem CellsCytokinesDrosophila ProteinsJanus KinasesN-AcetylgalactosaminyltransferasesPGANT4 protein, DrosophilaSTAT Transcription FactorsUpd3 protein, DrosophilaDrosophilaglycosylationinterleukin 6 (IL-6)JAK/STATmucinmucous membranemucusnicheO-glycosylationperitrophic membraneprogenitor cellTango1Upd3

Identifiers

PMID29127201
PMCPMC5766965
OpenAlexW2789618039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.