Evidence map›Paper›PMID 29127147›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

IgG1 Is Required for Optimal Protection after Immunization with the Purified Porin OmpD from

Yang Zhang, Coral Dominguez-Medina, Nicola J Cumley, Jennifer N Heath, Sarah J Essex, Saeeda Bobat, Anna Schager, Margaret Goodall, Sven Kracker, Christopher D Buckley and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  7. Multivalent vaccines for invasiveInfection and immunity · 2026
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  11. A Fluorinated Sialic Acid Vaccine Lead Against Meningitis B and C.Journal of the American Chemical Society · 2024
    Article
  12. Article
  13. Article
  14. Infection and immunity · 2021
    Article
  15. Article
  16. Antibodies and Protection in SystemicInfection and immunity · 2020
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Yang ZhangInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, United Kingdom.ORCID 0000-0002-4201-3702
Coral Dominguez-MedinaInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, United Kingdom.ORCID 0000-0002-6071-9995
Nicola J CumleySchool of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.
Jennifer N HeathInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, United Kingdom.
Sarah J EssexSchool of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.
Saeeda BobatInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, United Kingdom.
Anna SchagerInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, United Kingdom.
Margaret GoodallInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, United Kingdom.
Sven KrackerDeutsches Rheuma-Forschungszentrum Berlin, Berlin 10117, Germany.
Christopher D BuckleyInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, United Kingdom.ORCID 0000-0001-6924-6402
Robin C MaySchool of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.ORCID 0000-0001-5364-1838
Robert A KingsleyWellcome Trust Sanger Institute, Cambridge CB10 1SA, United Kingdom.
Calman A MacLennanInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, United Kingdom.
Constantino López-MacíasMedical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre Siglo XXI, Mexican Social Security Institute, 06720 México, DF, Mexico; and.ORCID 0000-0003-0530-492X
Adam F CunninghamInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, United Kingdom; k.m.toellner@bham.ac.uk a.f.cunningham@bham.ac.uk.
Kai-Michael ToellnerInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, United Kingdom; k.m.toellner@bham.ac.uk a.f.cunningham@bham.ac.uk.ORCID 0000-0001-8404-645X
NIHR Birmingham Biomedical Research Centre · GBUniversity of Birmingham · GBGerman Rheumatism Research Centre · DEMexican Social Security Institute · MXWellcome Sanger Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L009986/1Medical Research Council G1001390Medical Research Council MR/N023706/1
6 · The paper itself

Abstract

In mice, the IgG subclass induced after Ag encounter can reflect the nature of the Ag. Th2 Ags such as alum-precipitated proteins and helminths induce IgG1, whereas Th1 Ags, such as

Indexed as

AnimalsAntibodies, BacterialAntigen-Antibody ReactionsBacterial AdhesionBacterial ProteinsCell LineFemaleIgG DeficiencyImmunizationImmunoglobulin Class SwitchingImmunoglobulin GImmunoglobulin IsotypesMaleMice, Inbred C57BLPhagocytosisPorinsAntibodies, BacterialBacterial ProteinsImmunoglobulin GImmunoglobulin IsotypesOmpD protein, Salmonella typhimuriumPorinsSalmonella Vaccines

Identifiers

PMID29127147
PMCPMC5713499
OpenAlexW2767558110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.