ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018
Protein Kinase C Epsilon Is a Key Regulator of Mitochondrial Redox Homeostasis in Acute Myeloid Leukemia.
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Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Ferroptosis in major depressive disorder: Molecular mechanisms, cellular vulnerability, and therapeutic opportunities.Biochemistry and biophysics reports · 2026Review
- Cell-Type-Specific Regulation of Ferroptosis in Atherosclerosis: Mechanisms and Therapeutic Potential of Natural Products.Cell biochemistry and function · 2026Review
- ATF4 coordinates amino acid and nucleotide synthesis with selective protein translation to ensure proper DNA replication timing in leukemia cells.Nature communications · 2026Article
- PKC isoforms in hematopoietic lineages and myeloid/lymphoid leukemias: mechanistic insights and therapeutic prospects.Frontiers in oncology · 2026Review
- Article
- Interplay between Protein Kinase C Epsilon and Reactive Oxygen Species during Myogenic Differentiation.Cells · 2023Article
- Role of Diacylglycerol Kinases in Acute Myeloid Leukemia.Biomedicines · 2023Article
- Tumor PKCδ instigates immune exclusion in EGFR-mutated non-small cell lung cancer.BMC medicine · 2022Article
- Protein Kinase C (PKC) Isozymes as Diagnostic and Prognostic Biomarkers and Therapeutic Targets for Cancer.Cancers · 2022Review
- The bone marrow niche regulates redox and energy balance in MLL::AF9 leukemia stem cells.Leukemia · 2022Article
- PKCε Activation Restores Loss of PKCε, Manganese Superoxide Dismutase, Vascular Endothelial Growth Factor, and Microvessels in Aged and Alzheimer's Disease Hippocampus.Frontiers in aging neuroscience · 2022Article
- Protein Kinase C Epsilon Overexpression Is Associated With Poor Patient Outcomes in AML and Promotes Daunorubicin Resistance Through p-Glycoprotein-Mediated Drug Efflux.Frontiers in oncology · 2022Article
- ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.Molecular cell · 2021Article
- Review
- Mitochondrial Redox Hubs as Promising Targets for Anticancer Therapy.Frontiers in oncology · 2020Review
- GATA-1 isoforms differently contribute to the production and compartmentation of reactive oxygen species in the myeloid leukemia cell line K562.Journal of cellular physiology · 2019Article
- Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia.Journal of visualized experiments : JoVE · 2019Article
- Emerging Therapies for Acute Myelogenus Leukemia Patients Targeting Apoptosis and Mitochondrial Metabolism.Cancers · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 1 institution in 1 country.
Daniela Di MarcantonioFox Chase Cancer Center, Philadelphia, Pennsylvania.
Esteban MartinezFox Chase Cancer Center, Philadelphia, Pennsylvania.
Simone SidoliPenn Epigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Jessica VadakethFox Chase Cancer Center, Philadelphia, Pennsylvania.
Margaret Nieborowska-SkorskaDepartment of Microbiology and Immunology, Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania.
Anushk GuptaFox Chase Cancer Center, Philadelphia, Pennsylvania.
Jake M MeadowsFox Chase Cancer Center, Philadelphia, Pennsylvania.
Francesca FerraroFox Chase Cancer Center, Philadelphia, Pennsylvania.
Elena MasselliDepartment of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy.
Grant A ChallenDivision of Oncology, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, Missouri.
Michael D MilsomDivision of Experimental Hematology, German Cancer Research Center (DKFZ) Heidelberg, Germany.
Claudia SchollDepartment of Translational Oncology, NCT Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Stefan FröhlingDepartment of Translational Oncology, NCT Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Siddharth BalachandranFox Chase Cancer Center, Philadelphia, Pennsylvania.
Tomasz SkorskiDepartment of Microbiology and Immunology, Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania.
Benjamin A GarciaPenn Epigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Prisco MirandolaDepartment of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy.
Giuliana GobbiDepartment of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy.
Ramiro GarzonDivision of Hematology, The Ohio State University, Columbus, Ohio.
Marco VitaleDepartment of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy.
Stephen M SykesFox Chase Cancer Center, Philadelphia, Pennsylvania. Stephen.Sykes@fccc.edu.
Fox Chase Cancer Center · US
Funding
WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8MTranslational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3MShared Resources Core 2: Quantitative Proteomics CoreP01CA196539 · NCI · ROCKEFELLER UNIVERSITY · PI MUIR, TOM · 2015 to 2024
$17.6MEPIGENTIC REGULATION OF HEMATOPOIETIC STEM CELL FUNCTION AND TRANSFORMATIONR01DK102428 · NIDDK · WASHINGTON UNIVERSITY · PI CHALLEN, GRANT ANTHONY · 2015 to 2019
$1.7MFoxo transcription factors are required for maintenance of acute myeloid leukemiaR00CA158461 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI SYKES, STEPHEN MATTHEW · 2012 to 2014
$641kNCI NIH HHS P01 CA196539NCI NIH HHS P30 CA006927NCI NIH HHS P30 CA016058NCI NIH HHS R00 CA158461NIDDK NIH HHS R01 DK102428
Abstract
PubMed holds no abstract for this paper.
Indexed as
Oxidation-ReductionAnimalsApoptosisCell Line, TumorCell ProliferationCell SurvivalGene Expression Regulation, LeukemicHomeostasisHumansIntracellular SpaceLeukemia, Myeloid, AcuteMiceMitochondriaProtein Kinase C-epsilonReactive Oxygen SpeciesSuperoxide DismutaseProtein Kinase C-epsilonReactive Oxygen SpeciesSuperoxide DismutaseSuperoxide Dismutase 2
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.