Evidence map›Paper›PMID 29127112›Full record

ArticleJournal of the American Society of Nephrology : JASN2018

Reduced Expression of Glutathione S-Transferase

Jinlong Luo, Guang Chen, Ming Liang, Aini Xie, Qingtian Li, Qunying Guo, Rajendra Sharma, Jizhong Cheng

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jinlong LuoDepartment of Emergency, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Guang ChenSelzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Ming LiangSelzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Aini XieSelzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Qingtian LiSelzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Qunying GuoSelzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Rajendra SharmaDepartment of Integrative Traditional Chinese & Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China; and.
Jizhong ChengSelzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas; jizhongc@bcm.edu.
Baylor College of Medicine · USTongji Hospital · CN

Funding

PROTEIN NUTRITION IN EXPERIMENTAL UREMIAR01DK037175 · NIDDK · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI Zhaoyong Hu · 1986 to 2026
$4.3M
PROTEIN NUTRITION IN EXPERIMENTAL UREMIAR37DK037175 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI MITCH, WILLIAM EVANS · 2006 to 2015
$3.8M
CHRONIC KIDNEY DISEASE ADVERSELY INFLUENCES VASCULAR FUNCTIONSR01DK095867 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI CHENG, JIZHONG · 2013 to 2017
$1.7M
NIDDK NIH HHS R01 DK037175NIDDK NIH HHS R01 DK095867NIDDK NIH HHS R37 DK037175
6 · The paper itself

Abstract

Neointima formation is the leading cause of arteriovenous fistula (AVF) failure. We have shown that CKD accelerates this process by transforming the vascular smooth muscle cells (SMCs) lining the AVF from a contractile to the synthetic phenotype. However, the underlying mechanisms affecting this transformation are not clear. Previous studies have shown that the

Indexed as

AldehydesAnimalsArteriesArteriovenous Shunt, SurgicalCell ProliferationDown-RegulationGene ExpressionGlutathione TransferaseHyperplasiaMAP Kinase Signaling SystemMiceMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaPhenotype4-hydroxy-2-nonenalAldehydesGlutathione TransferaseGSTA4-4 protein, mouseRNA, Messengerarteriovenous fistulachronic kidney diseaseglutathione S-transferase A4neointima

Identifiers

PMID29127112
PMCPMC5791085
OpenAlexW2767444379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.