Evidence map›Paper›PMID 29127045›Full record

ReviewSeminars in cell & developmental biology2017

The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration.

J Manuel Hernández-Hernández, Estela G García-González, Caroline E Brun, Michael A Rudnicki

Open access · hybridAbstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 391 papers.

0numbers the graph read from it
0cells of the map it votes in
391citing papers in PubMed
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

391 citing papers in PubMed, 652 citations in OpenAlex.

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  12. Developmental expression of the skeletal muscle determination gene,bioRxiv : the preprint server for biology · 2026
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331 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

J Manuel Hernández-HernándezThe Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada; Departments of Medicine and Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
Estela G García-GonzálezThe Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada; Departments of Medicine and Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
Caroline E BrunThe Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada; Departments of Medicine and Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
Michael A RudnickiThe Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada; Departments of Medicine and Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada. Electronic address: mrudnicki@ohri.ca.
University of Ottawa · CAOttawa Hospital · CAOttawa Hospital Research Institute

Funding

GENETIC REGULATION OF SKELETAL MUSCLE REPAIRR01AR044031 · NIAMS · OTTAWA HOSPITAL RESEARCH INSTITUTE · PI RUDNICKI, MICHAEL A · 1996 to 2025
$5.6M
CIHR ERA-132935CIHR FDN-148387NIAMS NIH HHS R01 AR044031
6 · The paper itself

Abstract

The Myogenic Regulatory Factors (MRFs) Myf5, MyoD, myogenin and MRF4 are members of the basic helix-loop-helix family of transcription factors that control the determination and differentiation of skeletal muscle cells during embryogenesis and postnatal myogenesis. The dynamics of their temporal and spatial expression as well as their biochemical properties have allowed the identification of a precise and hierarchical relationship between the four MRFs. This relationship establishes the myogenic lineage as well as the maintenance of the terminal myogenic phenotype. The application of genome-wide technologies has provided important new information as to how the MRFs function to activate muscle gene expression. Application of combined functional genomics technologies along with single cell lineage tracing strategies will allow a deeper understanding of the mechanisms mediating myogenic determination, cell differentiation and muscle regeneration.

Indexed as

AnimalsCell DifferentiationCell LineageGene Expression Regulation, DevelopmentalMiceMuscle DevelopmentMuscle, SkeletalMyogenic Regulatory FactorsPhylogenyRegenerationMyogenic Regulatory FactorsMyoDMyogenesisMyogenic regulatory factorsSkeletal muscle

Identifiers

PMID29127045
PMCPMC5723221
OpenAlexW2769276755

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.