ArticleBrain stimulation
Sensory percepts induced by microwire array and DBS microstimulation in human sensory thalamus.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Clinical Applications and Future Translation of Somatosensory Neuroprostheses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- The role of stimulus periodicity on spinal cord stimulation-induced artificial sensations in rodents.Journal of neural engineering · 2024Article
- Neuromorphic hardware for somatosensory neuroprostheses.Nature communications · 2024Review
- Restoration of sensory information via bionic hands.Nature biomedical engineering · 2023Review
- On closed-loop brain stimulation systems for improving the quality of life of patients with neurological disorders.Frontiers in human neuroscience · 2023Review
- Microscale multicircuit brain stimulation: Achieving real-time brain state control for novel applications.Current research in neurobiology · 2023Review
- DyNeuMo Mk-1: Design and pilot validation of an investigational motion-adaptive neurostimulator with integrated chronotherapy.Experimental neurology · 2022Article
- Review
- Article
- Microstimulation Is a Promising Approach in Achieving Better Lead Placement in Subthalamic Nucleus Deep Brain Stimulation Surgery.Frontiers in neurology · 2021Article
- Stimulation and Recording of the Hippocampus Using the Same Pt-Ir Coated Microelectrodes.Frontiers in neuroscience · 2021Article
- A comprehensive model-based framework for optimal design of biomimetic patterns of electrical stimulation for prosthetic sensation.Journal of neural engineering · 2020Article
- A Brain to Spine Interface for Transferring Artificial Sensory Information.Scientific reports · 2020Article
- Neural Circuit and Clinical Insights from Intraoperative Recordings During Deep Brain Stimulation Surgery.Brain sciences · 2019Article
- Adding wisdom to 'smart' bioelectronic systems: a design framework for physiologic control including practical examples.Bioelectronics in medicine · 2019Article
- A Multi-Channel Asynchronous Neurostimulator With Artifact Suppression for Neural Code-Based Stimulations.Frontiers in neuroscience · 2019Article
- Distinct perceptive pathways selected with tonic and bursting patterns of thalamic stimulation.Brain stimulationArticle
- Generating artificial sensations with spinal cord stimulation in primates and rodents.Brain stimulationArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMicrostimulation in human sensory thalamus (ventrocaudal, VC) results in focal sensory percepts in the hand and arm which may provide an alternative target site (to somatosensory cortex) for the input of prosthetic sensory information. Sensory feedback to facilitate motor function may require simultaneous or timed responses across separate digits to recreate perceptions of slip as well as encoding of intensity variations in pressure or touch.
objectivesTo determine the feasibility of evoking sensory percepts on separate digits with variable intensity through either a microwire array or deep brain stimulation (DBS) electrode, recreating "natural" and scalable percepts relating to the arm and hand.
methodsWe compared microstimulation within ventrocaudal sensory thalamus through either a 16-channel microwire array (∼400 kΩ per channel) or a 4-channel DBS electrode (∼1.2 kΩ per contact) for percept location, size, intensity, and quality sensation, during thalamic DBS electrode placement in patients with essential tremor.
resultsPercepts in small hand or finger regions were evoked by microstimulation through individual microwires and in 5/6 patients sensation on different digits could be perceived from stimulation through separate microwires. Microstimulation through DBS electrode contacts evoked sensations over larger areas in 5/5 patients, and the apparent intensity of the perceived response could be modulated with stimulation amplitude. The perceived naturalness of the sensation depended both on the pattern of stimulation as well as intensity of the stimulation.
conclusionsProducing consistent evoked perceptions across separate digits within sensory thalamus is a feasible concept and a compact alternative to somatosensory cortex microstimulation for prosthetic sensory feedback. This approach will require a multi-element low impedance electrode with a sufficient stimulation range to evoke variable intensities of perception and a predictable spread of contacts to engage separate digits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.