Evidence map›Paper›PMID 29126704›Full record

ArticleEpilepsy & behavior : E&B2018

Decreased neurite density within frontostriatal networks is associated with executive dysfunction in temporal lobe epilepsy.

Anny Reyes, Vedang S Uttarwar, Yu-Hsuan A Chang, Akshara R Balachandra, Chris J Pung, Donald J Hagler, Briana M Paul, Carrie R McDonald

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy & behavior : E&B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Neurobehavioral and Clinical Comorbidities in Epilepsy: The Role of White Matter Network Disruption.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024
    Review
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  6. Article
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  8. Article
  9. Cognitive slowing and its underlying neurobiology in temporal lobe epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2019
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Anny ReyesSan Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA; Center for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
Vedang S UttarwarCenter for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
Yu-Hsuan A ChangCenter for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
Akshara R BalachandraCenter for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
Chris J PungCenter for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
Donald J HaglerCenter for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
Briana M PaulDepartment of Neurology, University of California - San Francisco, San Francisco, CA, USA; UCSF Comprehensive Epilepsy Center, San Francisco, CA, USA.
Carrie R McDonaldSan Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA; Center for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, CA, USA. Electronic address: camcdonald@ucsd.edu.
University of California, San Diego · USSan Diego State University · USUniversity of California, San Francisco · US

Funding

Multimodal Imaging of Language in the Preoperative Evaluation of EpilepsyR01NS065838 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2010 to 2018
$4.4M
NINDS NIH HHS R01 NS065838
6 · The paper itself

Abstract

objectiveExecutive dysfunction is observed in a sizable number of patients with refractory temporal lobe epilepsy (TLE). The frontostriatal network has been proposed to play a significant role in executive functioning, however, because of the complex architecture of these tracts, it is difficult to generate measures of fiber tract microstructure using standard diffusion tensor imaging. To examine the association between frontostriatal network compromise and executive dysfunction in TLE, we applied an advanced, multishell diffusion model, restriction spectrum imaging (RSI), that isolates measures of intraaxonal diffusion and may provide better estimates of fiber tract compromise in TLE.

methodsRestriction spectrum imaging scans were obtained from 32 patients with TLE [16 right TLE (RTLE); 16 left TLE (LTLE)] and 24 healthy controls (HC). An RSI-derived measure of intraaxonal anisotropic diffusion (neurite density; ND) was calculated for the inferior frontostriatal tract (IFS) and superior frontostriatal tract (SFS) and compared between patients with TLE and HC. Spearman correlations were performed to evaluate the relationships between ND of each tract and verbal (i.e., D-KEFS Category Switching Accuracy and Color-Word Interference Inhibition/Switching) and visuomotor (Trail Making Test) set-shifting performances in patients with TLE.

resultsPatients with TLE demonstrated reductions in ND of the left and right IFS, but not SFS, compared with HC. Reduction in ND of left and right IFS was associated with poorer performance on verbal set-shifting in TLE. Increases in extracellular diffusion (isotropic hindered; IH) were not associated with executive dysfunction in the patient group. SIGNIFICANCE: Restriction spectrum imaging-derived ND revealed microstructural changes within the IFS in patients with TLE, which was associated with poorer executive functioning. This suggests that axonal/myelin loss to fiber networks connecting the striatum to the inferior frontal cortex is likely contributing to executive dysfunction in TLE.

Indexed as

Executive FunctionNeuritesAdultDiffusion Tensor ImagingEpilepsy, Temporal LobeFemaleFrontal LobeHumansMagnetic Resonance ImagingMaleMental DisordersMiddle AgedNeuropsychological TestsTemporal LobeTrail Making TestAdvanced diffusionDemyelinationExecutive functionInhibitionSet-shifting

Identifiers

PMID29126704
PMCPMC5756677
OpenAlexW2767891364

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.