ArticleNeurosurgery2018
Seizure Outcome After Surgical Resection of Insular Glioma.
Article in Neurosurgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Repeated awake surgery and quality of life in patients with diffuse glioma: a systematic review and meta-analysis.Neurosurgical review · 2023Pooled it
- Seizure outcome after resection of insular glioma: a systematic review, meta-analysis, and institutional experience.Journal of neurosurgery · 2023Pooled it
- Health-related quality of life outcomes of surgery for diffuse glioma: A systematic review and pooled analysis.Neuro-oncology practice · 2026Review
- Surgical timing guided by progressive cognitive decline in a left insular tumor without neurological deficits: A case report.Surgical neurology international · 2026Article
- Long-Term Follow-Up Results of Antiseizure Medication Withdrawal in Grade 2 and 3 Glioma Patients: A Prospective Observational Study.Neurology · 2025Observational
- Epilepsy as primary tumor manifestation correlates with patient status, age, and tumor volume but not with survival in elderly glioblastoma patients: a retrospective bicentric analysis.Neurosurgical review · 2025Article
- From bench to bedside: the application of cannabidiol in glioma.Journal of translational medicine · 2024Review
- Prognostic Factors and Resectability Predictors in Insular Gliomas: A Systematic Review.Journal of neurological surgery. Part A, Central European neurosurgery · 2024Article
- Surgical treatment for insular gliomas. A systematic review and meta-analysis on behalf of the EANS neuro-oncology section.Brain & spine · 2024Review
- TXNDC12 knockdown promotes ferroptosis by modulating SLC7A11 expression in glioma.Clinical and translational science · 2023Article
- Postoperative risk of IDH-mutant glioma-associated seizures and their potential management with IDH-mutant inhibitors.The Journal of clinical investigation · 2023Article
- Benign Glioma.Advances in experimental medicine and biology · 2023Article
- Article
- Clinical and prognostic implications of rim restriction following glioma surgery.Scientific reports · 2022Article
- Article
- Challenging Giant Insular Gliomas With Brain Mapping: Evaluation of Neurosurgical, Neurological, Neuropsychological, and Quality of Life Results in a Large Mono-Institutional Series.Frontiers in oncology · 2021Article
- Functional Mapping for Glioma Surgery, Part 2: Intraoperative Mapping Tools.Neurosurgery clinics of North America · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundA majority of patients with insular tumors present with seizures. Although a number of studies have shown that greater extent of resection improves overall patient survival, few studies have documented postoperative seizure control after insular tumor resection.
objectiveTo (1) characterize seizure control rates in patients undergoing insular tumor resection, (2) identify predictors of seizure control, and (3) evaluate the association between seizure recurrence and tumor progression.
methodsThe study population included adults who had undergone resection of insular gliomas between 1997 and 2015 at our institution. Preoperative seizure characteristics, tumor characteristics, surgical factors, and postoperative seizure outcomes were reviewed.
resultsOne-hundred nine patients with sufficient clinical data were included in the study. At 1 yr after surgery, 74 patients (68%) were seizure free. At final follow-up, 42 patients (39%) were seizure free. Median time to seizure recurrence was 46 mo (95% confidence interval 31-65 mo). Multivariate Cox regression analysis revealed that greater extent of resection (hazard ratio = 0.2899 [0.1129, 0.7973], P = .0127) was a significant predictor of seizure freedom. Of patients who had seizure recurrence and tumor progression, seizure usually recurred within 3 mo prior to tumor progression. Repeat resection offered additional seizure control, as 8 of the 22 patients with recurrent seizures became seizure free after reoperation.
conclusionMaximizing the extent of resection in insular gliomas portends greater seizure freedom after surgery. Seizure recurrence is associated with tumor progression, and repeat operation can provide additional seizure control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.