Evidence map›Paper›PMID 29126174›Full record

ArticleNucleic acids research2018

miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions.

Chih-Hung Chou, Sirjana Shrestha, Chi-Dung Yang, Nai-Wen Chang, Yu-Ling Lin, Kuang-Wen Liao, Wei-Chi Huang, Ting-Hsuan Sun, Siang-Jyun Tu, Wei-Hsiang Lee and 26 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,037 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,037citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,037 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  19. Construction and Analysis of miRNA Regulatory Networks.Methods in molecular biology (Clifton, N.J.) · 2026
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977 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Chih-Hung ChouInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Sirjana ShresthaDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Chi-Dung YangDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Nai-Wen ChangGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, 106, Taiwan.
Yu-Ling LinDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Kuang-Wen LiaoDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Wei-Chi HuangInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Ting-Hsuan SunDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Siang-Jyun TuInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Wei-Hsiang LeeDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Men-Yee ChiewDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Chun-San TaiDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Ting-Yen WeiInterdisciplinary Program of Life Science, National Tsing Hua University, Hsinchu, 300, Taiwan.
Tzi-Ren TsaiDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Hsin-Tzu HuangDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Chung-Yu WangInstitute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
Hsin-Yi WuInstitute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
Shu-Yi HoDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Pin-Rong ChenInstitute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
Cheng-Hsun ChuangInstitute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
Pei-Jung HsiehDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Yi-Shin WuDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Wen-Liang ChenDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Meng-Ju LiDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Yu-Chun WuDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Xin-Yi HuangDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Fung Ling NgDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Waradee BuddhakosaiDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Pei-Chun HuangDelivery Room, Department of Nursing, National Taiwan University Hospital Hsinchu Branch, Hsinchu, 300, Taiwan.
Kuan-Chun LanInstitute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
Chia-Yen HuangDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Shun-Long WengDepartment of Obstetrics and Gynecology, Hsinchu Mackay Memorial Hospital, Hsinchu, 300, Taiwan.
Yeong-Nan ChengInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Chao LiangInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Wen-Lian HsuInstitute of Information Science, Academia Sinica, Taipei, 115, Taiwan.
Hsien-Da HuangInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs of ∼ 22 nucleotides that are involved in negative regulation of mRNA at the post-transcriptional level. Previously, we developed miRTarBase which provides information about experimentally validated miRNA-target interactions (MTIs). Here, we describe an updated database containing 422 517 curated MTIs from 4076 miRNAs and 23 054 target genes collected from over 8500 articles. The number of MTIs curated by strong evidence has increased ∼1.4-fold since the last update in 2016. In this updated version, target sites validated by reporter assay that are available in the literature can be downloaded. The target site sequence can extract new features for analysis via a machine learning approach which can help to evaluate the performance of miRNA-target prediction tools. Furthermore, different ways of browsing enhance user browsing specific MTIs. With these improvements, miRTarBase serves as more comprehensively annotated, experimentally validated miRNA-target interactions databases in the field of miRNA related research. miRTarBase is available at http://miRTarBase.mbc.nctu.edu.tw/.

Indexed as

Databases, GeneticData MiningHumansMicroRNAsRNA, MessengerUser-Computer InterfaceMicroRNAsRNA, Messenger

Identifiers

PMID29126174
PMCPMC5753222

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.