ArticleMolecular biology and evolution2018
Mode and Rate of Evolution of Haemosporidian Mitochondrial Genomes: Timing the Radiation of Avian Parasites.
Article in Molecular biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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86 citing papers in PubMed, 180 citations in OpenAlex.
- The monophyly of Nycteria and Polychromophilus parasites: a missing piece in the evolution of malaria and other Haemosporida.Malaria journal · 2026Article
- New mitochondrial genomes of parasites belonging to the Leucocytozoon toddi and Haemoproteus nisi groups (Haemosporida, Apicomplexa).Parasites & vectors · 2026Article
- Use of Contaminated Habitat and Associated Selenium Uptake Mediate Haemosporidian Parasite Infections in Wild Passerine Birds.Ecology and evolution · 2026Article
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- Haemoproteus syrnii and other haemosporidians infecting owls from North America.Malaria journal · 2025Article
- Phylogenomics redefines the evolutionary history of mosquitoes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Phylogenetic assessment ofParasitology · 2025Article
- Unraveling the host range ofParasitology · 2025Article
- Imprudent use of MalAvi names biases the estimation of parasite diversity of avian haemosporidians.PLoS pathogens · 2025Article
- Characterization of co-infections of haemosporidian parasites in SwinhoeCurrent research in parasitology & vector-borne diseases · 2025Article
- Diversity of haemosporidian parasites in cranes: description of Haemoproteus balearicae and its phylogenetic position within the H. antigonis clade.Parasite (Paris, France) · 2025Article
- A generalist vector-transmitted parasite exhibits population genetic structure among host genera.Parasitology · 2025Article
- HiddenCurrent research in parasitology & vector-borne diseases · 2025Article
- Remarkable Evolutionary Rate Variations Among Lineages and Among Genome Compartments in Malaria Parasites of Mammals.Molecular biology and evolution · 2024Article
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- The prevalence and immune response to coinfection by avian haemosporidians in wild Eurasian blackbirdsParasitology · 2024Article
- Identification of Haemoproteus infection in an imported grey crowned crane (Balearica regulorum) in China.Parasitology research · 2024Article
- Modeling Substitution Rate Evolution across Lineages and Relaxing the Molecular Clock.Genome biology and evolution · 2024Review
26 more citing papers are in PubMed but not listed here.
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11 authors at 7 institutions in 4 countries.
Funding
Abstract
Haemosporidians are a diverse group of vector-borne parasitic protozoa that includes the agents of human malaria; however, most of the described species are found in birds and reptiles. Although our understanding of these parasites' diversity has expanded by analyses of their mitochondrial genes, there is limited information on these genes' evolutionary rates. Here, 114 mitochondrial genomes (mtDNA) were studied from species belonging to four genera: Leucocytozoon, Haemoproteus, Hepatocystis, and Plasmodium. Contrary to previous assertions, the mtDNA is phylogenetically informative. The inferred phylogeny showed that, like the genus Plasmodium, the Leucocytozoon and Haemoproteus genera are not monophyletic groups. Although sensitive to the assumptions of the molecular dating method used, the estimated times indicate that the diversification of the avian haemosporidian subgenera/genera took place after the Cretaceous-Paleogene boundary following the radiation of modern birds. Furthermore, parasite clade differences in mtDNA substitution rates and strength of negative selection were detected. These differences may affect the biological interpretation of mtDNA gene lineages used as a proxy to species in ecological and parasitological investigations. Given that the mitochondria are critically important in the parasite life cycle stages that take place in the vector and that the transmission of parasites belonging to particular clades has been linked to specific insect families/subfamilies, this study suggests that differences in vectors have affected the mode of evolution of haemosporidian mtDNA genes. The observed patterns also suggest that the radiation of haemosporidian parasites may be the result of community-level evolutionary processes between their vertebrate and invertebrate hosts.
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