ArticleNeurosurgery2018
Cranial Chordoma: A New Preoperative Grading System.
Article in Neurosurgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Apparent diffusion coefficient as a prognostic factor in clival chordoma.Scientific reports · 2021Trial
- Machine learning in automatic detection of chordoma signature, postoperative residuals, and prognosis of skull base chordomas.NPJ precision oncology · 2026Article
- Chordoma: Genetics and Contemporary Management.International journal of molecular sciences · 2024Review
- Predicting overall survival in chordoma patients using machine learning models: a web-app application.Journal of orthopaedic surgery and research · 2023Article
- Proton or Carbon Ion Therapy for Skull Base Chordoma: Rationale and First Analysis of a Mono-Institutional Experience.Cancers · 2023Article
- The transnasal endoscopic approach for resection of clival tumors: a single-center experience.Scientific reports · 2023Article
- Skull Base Registries: A Roadmap.Journal of neurological surgery. Part B, Skull base · 2022Review
- Clinical Grading System, Surgical Outcomes and Prognostic Analysis of Cranial Base Chordomas.Journal of Korean Neurosurgical Society · 2022Article
- Mid-term follow-up surgical results in 284 cases of clival chordomas: the risk factors for outcome and tumor recurrence.Neurosurgical review · 2022Article
- High systemic inflammation score is associated with adverse survival in skull base chordoma.Frontiers in oncology · 2022Article
- Development and validation of a preoperative MRI-based radiomics nomogram to predict progression-free survival in patients with clival chordomas.Frontiers in oncology · 2022Article
- Use of Salvage Surgery or Stereotactic Radiosurgery for Multiply Recurrent Skull Base Chordomas: A Single-Institution Experience and Review of the Literature.Journal of neurological surgery. Part B, Skull base · 2021Article
- Surgical Management of Skull Base and Spine Chordomas.Current treatment options in oncology · 2021Review
- Multivariate Analysis and Validation of the Prognostic Factors for Skull Base Chordoma.Frontiers in surgery · 2021Article
- A Review of Particle Therapy for Skull Base Tumors: Modern Considerations and Future Directions.International journal of particle therapy · 2021Article
- Endoscopic Endonasal Surgical Strategy for Skull Base Chordomas Based on Tumor Growth Directions: Surgical Outcomes of 167 Patients During 3 Years.Frontiers in oncology · 2021Article
- Prognostic impact of the "Sekhar grading system for cranial Chordomas" in patients treated with pencil beam scanning proton therapy: an institutional analysis.Radiation oncology (London, England) · 2020Article
- Identification of the Different Roles and Potential Mechanisms of T Isoforms in the Tumor Recurrence and Cell Cycle of Chordomas.OncoTargets and therapy · 2019Article
- Endoscopic transnasal surgery of clival lesions: our experience.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChordomas are rare but challenging neoplasms involving the skull base. A preoperative grading system will be useful to identify both areas for treatment and risk factors, and correlate to the degree of resection, complications, and recurrence.
objectiveTo propose a new grading system for cranial chordomas designed by the senior author. Its purpose is to enable comparison of different tumors with a similar pathology to clivus chordoma, and statistically correlate with postoperative outcomes.
methodsThe numerical grading system included tumor size, site of the tumor, vascular encasement, intradural extension, brainstem invasion, and recurrence of the tumor either after surgery or radiotherapy with a range of 2 to 25 points; it was used in 42 patients with cranial chordoma. The grading system was correlated with number of operations for resection, degree of resection, number and type of complications, recurrence, and survival.
resultsWe found 3 groups: low-risk 0 to 7 points, intermediate-risk 8 to 12 points, and high-risk ≥13 points in the grading system. The 3 groups were correlated with the following: extent of resection (partial, subtotal, or complete; P < .002); number of operative stages to achieve removal (P < .014); tumor recurrence (P = .03); postoperative Karnofsky Performance Status (P < .001); and with successful outcome (P = .005). The grading system itself correlated with the outcome (P = .005).
conclusionThe proposed chordoma grading system can help surgeons to predict the difficulty of the case and know which areas of the skull base will need attention to plan further therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.