ArticleFoot (Edinburgh, Scotland)2017
Histomorphological and biochemical properties of plantar soft tissue in diabetes.
Article in Foot (Edinburgh, Scotland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Validation and reliability of mechanical stiffness assessment tools in multilayered polyurethane phantom models of healthy and diabetic plantar soft tissues.Scientific reports · 2025Article
- [Development and Validation of a Risk Prediction Model for Prolonged Hospitalization in Patients With Diabetic Foot Ulcers].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- An exploratory in-situ dynamic mechanical analysis on the shearing stress-strain mechanism of human plantar soft tissue.Scientific reports · 2024Article
- Article
- A narrative review of the measurement methods for biomechanical properties of plantar soft tissue in patients with diabetic foot.Frontiers in endocrinology · 2024Review
- Change in the sub-sesamoid soft tissue thickness under different loading conditions.Journal of physical therapy science · 2023Article
- Effect of loading history on material properties of human heel pad: an in-vivo pilot investigation during gait.BMC musculoskeletal disorders · 2022Article
- Diabetes Status is Associated With Plantar Soft Tissue Stiffness Measured Using Ultrasound Reverberant Shear Wave Elastography Approach.Journal of diabetes science and technology · 2022Article
- Comparison of material properties of heel pad between adults with and without type 2 diabetes history: AnFrontiers in endocrinology · 2022Article
- The compressive, shear, biochemical, and histological characteristics of diabetic and non-diabetic plantar skin are minimally different.Journal of biomechanics · 2021Article
- Comparison of texture-based classification and deep learning for plantar soft tissue histology segmentation.Computers in biology and medicine · 2021Article
- The association between mechanical and biochemical/histological characteristics in diabetic and non-diabetic plantar soft tissue.Journal of biomechanics · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundDiabetes results in pathophysiological changes, leading to tissue that is unable to withstand and adapt to the same loads, resulting in breakdown. Certain locations are more susceptible to breakdown, yet differences between locations are largely not well understood. The authors performed a histological and biochemical analysis of isolated plantar adipose tissue at six relevant locations.
methodsTissue from six plantar locations (hallux, first, third and fifth metatarsal heads, lateral midfoot and calcaneus) was taken from fresh cadaveric feet of older diabetic and older non-diabetic intact donors. Histomorphological and biochemical analysis of isolated plantar tissue from both diabetic and non-diabetic feet at six relevant locations was performed.
resultsThe main differences found between diabetic and non-diabetic tissue were in the thickness of the septal walls and the elastin content. Diabetic tissue had significantly thicker septal walls and an increased elastin concentration. When comparing the calcaneus to other locations, although there were no differences found in the thickness of the septal walls of diabetic tissue, elastin content was lower in the calcaneous tissue compared to the non-calcaneus sites.
conclusionsModifications in the structural and biochemical properties could translate to changes in the mechanical properties. This information could lead to an understanding of how the structural and biochemical changes result in an increase in susceptibility of tissue to breakdown with load at the different locations of the foot.
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