ArticlePloS one2017
Drug abusers have impaired cerebral oxygenation and cognition during exercise.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- The effects of exercise interventions on substance-use outcomes: A meta-analytic and systematic review.Experimental and clinical psychopharmacology · 2025Pooled it
- Associations between incremental exercise capacity and multimodal brain characteristics across training levels.Frontiers in human neuroscience · 2026Article
- Emerging panorama of functional near-infrared spectroscopy in Latin America.Neurophotonics · 2026Article
- Prefrontal Cortex Oxygenation During Exercise in Older Adults with Motoric Cognitive Risk Syndrome.Advanced biology · 2025Article
- Article
- Long-Term Effects of Mind-Body Exercises on the Physical Fitness and Quality of Life of Individuals With Substance Use Disorder-A Randomized Trial.Frontiers in psychiatry · 2020Article
- Rewiring the Addicted Brain Through a Psychobiological Model of Physical Exercise.Frontiers in psychiatry · 2019Review
- Cardiorespiratory Fitness Predicts Greater Vagal Autonomic Activity in Drug Users Under Stress.Substance abuse : research and treatment · 2019Article
- Article
- Anaerobic Exercise Training in the Therapy of Substance Use Disorders: A Systematic Review.Frontiers in psychiatry · 2018Article
- Interaction Between Stress and Addiction: Contributions From Latin-American Neuroscience.Frontiers in psychology · 2018Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndividuals with Substance Use Disorder (SUD) have lower baseline metabolic activity of the prefrontal cortex (PFC) associated with impairment of cognitive functions in decision-making and inhibitory control. Aerobic exercise has shown to improve PFC function and cognitive performance, however, its effects on SUD individuals remain unclear. PURPOSE: To verify the cognitive performance and oxygenation of the PFC during an incremental exercise in SUD individuals.
methodsFourteen individuals under SUD treatment performed a maximum graded exercise test on a cycle ergometer with continuous measurements of oxygen consumption, PFC oxygenation, and inhibitory control (Stroop test) every two minutes of exercise at different intensities. Fifteen non-SUD individuals performed the same protocol and were used as control group.
resultsExercise increased oxyhemoglobin (O2Hb) and total hemoglobin (tHb) by 9% and 7%, respectively. However, when compared to a non-SUD group, this increase was lower at high intensities (p<0.001), and the inhibitory cognitive control was lower at rest and during exercise (p<0.007). In addition, PFC hemodynamics during exercise was inversely correlated with inhibitory cognitive performance (reaction time) (r = -0.62, p = 0.001), and a lower craving perception for the specific abused substance (p = 0.0189) was reported immediately after exercise.
conclusionDespite SUD individuals having their PFC cerebral oxygenation increased during exercise, they presented lower cognition and oxygenation when compared to controls, especially at elevated intensities. These results may reinforce the role of exercise as an adjuvant treatment to improve PFC function and cognitive control in individuals with SUD.
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