Evidence map›Paper›PMID 29125762›Full record

ArticleJournal of medicinal chemistry2017

Highly Selective Dopamine D

Sean W Reilly, Suzy Griffin, Michelle Taylor, Kristoffer Sahlholm, Chi-Chang Weng, Kuiying Xu, Daniel A Jacome, Robert R Luedtke, Robert H Mach

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Frontiers in neuroscience · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. Identification of Novel Dopamine DMolecules (Basel, Switzerland) · 2022
    Article
  6. Article
  7. Pseudonatural Products Occur Frequently in Biologically Relevant Compounds.Journal of chemical information and modeling · 2021
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sean W ReillyDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-1656-1895
Suzy GriffinDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center , 3500 Camp Bowie Boulevard, Fort Worth, Texas 76107, United States.
Michelle TaylorDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center , 3500 Camp Bowie Boulevard, Fort Worth, Texas 76107, United States.
Kristoffer SahlholmDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania 19104, United States.
Chi-Chang WengDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania 19104, United States.
Kuiying XuDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania 19104, United States.
Daniel A JacomeDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania , 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, United States.
Robert R LuedtkeDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center , 3500 Camp Bowie Boulevard, Fort Worth, Texas 76107, United States.
Robert H MachDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-7645-2869

Funding

PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM008076 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A · 1985 to 2023
$10.8M
T32 Translational Addiction Research Fellowship ProgramT32DA028874 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI Julie A Blendy, Anna Rose Childress · 2010 to 2026
$5.0M
PET RADIOTRACERS FOR IMAGING THE DOPAMINE D3 RECEPTORR01DA029840 · NIDA · WASHINGTON UNIVERSITY · PI MACH, ROBERT H · 2010 to 2020
$4.3M
D3 Receptor Compounds for the Treatment of Psychostimulant AbuseR01DA023957 · NIDA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI LUEDTKE, ROBERT R · 2007 to 2017
$4.1M
NEUROBIOLOGY OF COCAINE-INDUCED BEHVRL SENSITIZATIONF32DA005589 · NIDA · WASHINGTON STATE UNIVERSITY · PI PIERCE, ROBERT CHRISTOPHER · 1993 to 1995
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NIDA NIH HHS F32 DA005589NIDA NIH HHS R01 DA023957NIDA NIH HHS R01 DA029840NIDA NIH HHS T32 DA028874NIGMS NIH HHS T32 GM008076
6 · The paper itself

Abstract

A series of potent and selective D

Indexed as

AlkanesAnimalsCell LineDopamine AntagonistsHumansLigandsPiperazinesRadioligand AssayReceptors, Dopamine D3Spiro CompoundsStructure-Activity RelationshipAlkanesDopamine AntagonistsLigandsPiperazinesReceptors, Dopamine D3Spiro Compounds

Identifiers

PMID29125762
PMCPMC5767125

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.