Evidence map›Paper›PMID 29125561›Full record

ArticleMolecules (Basel, Switzerland)2017

Dimethyl Sulfoxide (DMSO) Decreases Cell Proliferation and TNF-α, IFN-γ, and IL-2 Cytokines Production in Cultures of Peripheral Blood Lymphocytes.

Lucas de Abreu Costa, Marcelo Henrique Fernandes Ottoni, Michaelle Geralda Dos Santos, Agnes Batista Meireles, Valéria Gomes de Almeida, Wagner de Fátima Pereira, Bethânia Alves de Avelar-Freitas, Gustavo Eustáquio Alvim Brito-Melo

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 179 citations in OpenAlex.

  1. Autologous cord bloodWorld journal of clinical pediatrics · 2025
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lucas de Abreu CostaImmunology Laboratory, Integrated Center for Health Research, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, MG 39100-000, Brazil. lucas.farmac@gmail.com.
Marcelo Henrique Fernandes OttoniImmunology Laboratory, Integrated Center for Health Research, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, MG 39100-000, Brazil. m.ottoni@yahoo.com.br.ORCID 0000-0002-2333-2775
Michaelle Geralda Dos SantosImmunology Laboratory, Integrated Center for Health Research, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, MG 39100-000, Brazil. michaellegsantos@gmail.com.
Agnes Batista MeirelesImmunology Laboratory, Integrated Center for Health Research, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, MG 39100-000, Brazil. agnesbm@gmail.com.
Valéria Gomes de AlmeidaImmunology Laboratory, Integrated Center for Health Research, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, MG 39100-000, Brazil. valeria.g.almeida@gmail.com.
Wagner de Fátima PereiraImmunology Laboratory, Integrated Center for Health Research, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, MG 39100-000, Brazil. wagnerufvjm@gmail.com.
Bethânia Alves de Avelar-FreitasImmunology Laboratory, Integrated Center for Health Research, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, MG 39100-000, Brazil. bethania.avelar@ict.ufvjm.edu.br.
Gustavo Eustáquio Alvim Brito-MeloImmunology Laboratory, Integrated Center for Health Research, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, MG 39100-000, Brazil. gbrito1998@yahoo.com.
Universidade Federal dos Vales do Jequitinhonha e Mucuri · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dimethylsulfoxide (DMSO) is an amphipathic molecule composed of a polar domain characterized by the sulfinyl and two nonpolar methyl groups, for this reason it is able to solubilize polar and nonpolar substances and transpose hydrophobic barriers. DMSO is widely used to solubilize drugs of therapeutic applications and studies indicated that 10%

Indexed as

Cell DeathCell ProliferationCells, CulturedDimethyl SulfoxideHemolysisHumansInterferon-gammaInterleukin-2LymphocytesTumor Necrosis Factor-alphaDimethyl SulfoxideInterferon-gammaInterleukin-2Tumor Necrosis Factor-alphaanti-inflammatory agentsdimethyl sulfoxidesolvents

Identifiers

PMID29125561
PMCPMC6150313
OpenAlexW2767404919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.