Evidence map›Paper›PMID 29125538›Full record

ArticleInternational journal of molecular sciences2017

Cigarette Smoke Regulates the Competitive Interactions between NRF2 and BACH1 for Heme Oxygenase-1 Induction.

Wen-Hsin Chang, Philip Thai, Jihao Xu, David C Yang, Reen Wu, Ching-Hsien Chen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Wen-Hsin ChangDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Center for Comparative Respiratory Biology and Medicine, University of California Davis, Davis, CA 95616, USA. cwh77160@gmail.com.
Philip ThaiDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Center for Comparative Respiratory Biology and Medicine, University of California Davis, Davis, CA 95616, USA. effectorbio@gmail.com.
Jihao XuDivision of Nephrology, Department of Internal Medicine, University of California Davis, Davis, CA 95616, USA. jihxu@ucdavis.edu.ORCID 0000-0003-4063-0608
David C YangDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Center for Comparative Respiratory Biology and Medicine, University of California Davis, Davis, CA 95616, USA. dvcyang@ucdavis.edu.
Reen WuDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Center for Comparative Respiratory Biology and Medicine, University of California Davis, Davis, CA 95616, USA. rwu@ucdavis.edu.
Ching-Hsien ChenDivision of Nephrology, Department of Internal Medicine, University of California Davis, Davis, CA 95616, USA. jchchen@ucdavis.edu.
University of California, Davis · USNational Taiwan University · TW

Funding

TRAINING IN COMPARATIVE LUNG BIOLOGY AND MEDICINET32HL007013 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI Elena Goncharova, Nicholas J. KENYON · 1985 to 2026
$10.1M
Regulation of Airway Mucin Gene Expression by Epigenetic MechanismR01HL096373 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WU, REEN · 2010 to 2013
$1.5M
NHLBI NIH HHS R01 HL096373NHLBI NIH HHS T32 HL007013
6 · The paper itself

Abstract

Cigarette smoke has been shown to trigger aberrant signaling pathways and pathophysiological processes; however, the regulatory mechanisms underlying smoke-induced gene expression remain to be established. Herein, we observed that two smoke-responsive genes,

Indexed as

Basic-Leucine Zipper Transcription FactorsBronchiCell LineCell NucleusCytochrome P-450 CYP1A1DNA-Binding ProteinsEpithelial CellsGene Expression RegulationHeme Oxygenase-1HumansNF-E2-Related Factor 2Oxidative StressPromoter Regions, GeneticProtein Interaction MapsSignal TransductionSmokingBACH1 protein, humanBasic-Leucine Zipper Transcription FactorsCYP1A1 protein, humanCytochrome P-450 CYP1A1DNA-Binding ProteinsHeme Oxygenase-1NFE2L2 protein, humanNF-E2-Related Factor 2airway epitheliumgene regulationHO-1NRF2smoke

Identifiers

PMID29125538
PMCPMC5713355
OpenAlexW2767399184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.