Evidence map›Paper›PMID 29125333›Full record

ArticleThe British journal of radiology2018

Enhanced pre-operative axillary staging using intradermal microbubbles and contrast-enhanced ultrasound to detect and biopsy sentinel lymph nodes in breast cancer: a potential replacement for axillary surgery.

Karina Cox, Sian Taylor-Phillips, Nisha Sharma, Jennifer Weeks, Philippa Mills, Ali Sever, Adrian Lim, Isobel Haigh, Mohamed Hashem, Tania de Silva and 3 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

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  11. Study on Sentinel Lymph Node and Its Lymphatic Drainage Pattern of Breast Cancer by Contrast-Enhanced Ultrasound.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Karina Cox1 Breast Surgery, Peggy Wood Breast Unit, Maidstone Hospital, Hermitage Lane , Peggy Wood Breast Unit, Maidstone Hospital, Hermitage Lane , Kent, Maidstone , UK.
Sian Taylor-Phillips2 WMS - Population Evidence and Technologies, University of Warwick , University of Warwick , Coventry , UK.
Nisha Sharma3 Breast Radiology, Leeds Breast Unit, St James's University Hospital, Beckett Street , Leeds Breast Unit, St James's University Hospital, Beckett Street , Leeds , UK.
Jennifer Weeks1 Breast Surgery, Peggy Wood Breast Unit, Maidstone Hospital, Hermitage Lane , Peggy Wood Breast Unit, Maidstone Hospital, Hermitage Lane , Kent, Maidstone , UK.
Philippa Mills1 Breast Surgery, Peggy Wood Breast Unit, Maidstone Hospital, Hermitage Lane , Peggy Wood Breast Unit, Maidstone Hospital, Hermitage Lane , Kent, Maidstone , UK.
Ali Sever4 Breast Radiology, Breast Care Unit, Kings College Hospital, Ground floor, Cheyne Wing, Denmark Hill , Breast Care Unit, Kings College Hospital, Ground floor, Cheyne Wing, Denmark Hill , Brixton, London , UK.
Adrian Lim5 Breast Radiology, Breast Unit, Charing Cross Hospital, Fulham Palace Road , Breast Unit, Charing Cross Hospital, Fulham Palace Road , London , UK.
Isobel Haigh3 Breast Radiology, Leeds Breast Unit, St James's University Hospital, Beckett Street , Leeds Breast Unit, St James's University Hospital, Beckett Street , Leeds , UK.
Mohamed Hashem1 Breast Surgery, Peggy Wood Breast Unit, Maidstone Hospital, Hermitage Lane , Peggy Wood Breast Unit, Maidstone Hospital, Hermitage Lane , Kent, Maidstone , UK.
Tania de Silva6 School of Surgery, Health Education Kent Surrey and Sussex , Health Education Kent Surrey and Sussex , London , UK.
Keshthra Satchithananda4 Breast Radiology, Breast Care Unit, Kings College Hospital, Ground floor, Cheyne Wing, Denmark Hill , Breast Care Unit, Kings College Hospital, Ground floor, Cheyne Wing, Denmark Hill , Brixton, London , UK.
Mengxing Tang7 Department of Bioengineering, Imperial College London , Imperial College London , London , UK.
Matthew Wallis8 Breast Radiology, Breast Unit, Addenbrooke's Treatment Centre , Breast Unit, Addenbrooke's Treatment Centre , Cambridge , UK.
Maidstone Hospital · GBKing's College Hospital · GBSt James's University Hospital · GBCharing Cross Hospital · GBHealth Education England · GBImperial College London · GBUniversity of Warwick · GB

Funding

Department of Health CDF-2016-09-018
6 · The paper itself

Abstract

objectiveTo compare the experience of four UK Centres in the use of intradermal microbubbles and contrast enhanced ultrasound (CEUS) to pre-operatively identify and biopsy sentinel lymph nodes (SLN) in patients with breast cancer.

methodsIn all centres, breast cancer patients had a microbubble/CEUS SLN core biopsy prior to axillary surgery and patients in Centres 1 and 2 had a normal greyscale axillary ultrasound. Data were collected between 2010 and 2016; 1361 from Centre 1 (prospective, sequential), 376 from Centre 2 (retrospective, sequential), 121 from Centre 3 (retrospective, selected) and 48 from Centre 4 (prospective, selected).

resultsSLN were successfully core biopsied in 80% (Centre 1), 79.6% (Centre 2), 77.5% (Centre 3) and 88% (Centre 4). The sensitivities to identify all SLN metastases were 46.9% [95% confidence intervals (CI) (39.4-55.1)], 52.5% [95% CI (39.1-65.7)], 46.4% [95% CI (27.5-66.1)] and 45.5% [95% CI (16.7-76.6)], respectively. The specificities were 99.7% [95% CI (I98.9-100)], 98.1% [95% CI (94.5-99.6)], 100% [95% CI (93.2-100%)] and 96.3% [95% CI (81-99.9)], respectively.The negative predictive values were 87.0% [95% CI (84.3-89.3)], 84.5% [95% CI (78.4-89.5)], 86.9% [95% CI (82.4-90.3)] and 86.2% [95% CI (78.4-91.5)], respectively. At Centres 1 and 2, 12/730 (1.6%) and 7/181 (4%), respectively, of patients with a benign microbubble/CEUS SLN core biopsy had two or more lymph node (LN) macrometastases found at the end of primary surgical treatment.

conclusionThe identification and biopsy of SLN using CEUS is a reproducible technique. Advances in knowledge: In the era of axillary conservation, microbubble/CEUS SLN core biopsy has the potential to succeed surgical staging of the axilla.

Indexed as

MicrobubblesUltrasonography, MammaryAdultAgedAged, 80 and overAxillaBreast NeoplasmsContrast MediaFemaleHumansLymphatic MetastasisMiddle AgedPreoperative CareProspective StudiesRetrospective StudiesSensitivity and SpecificityContrast Media

Identifiers

PMID29125333
PMCPMC5965773
OpenAlexW2767748732

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.