ArticleBiomacromolecules2018
Nonswelling Thiol-Yne Cross-Linked Hydrogel Materials as Cytocompatible Soft Tissue Scaffolds.
Article in Biomacromolecules, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 99 citations in OpenAlex.
- Generating structurally and functionally programmable hydrogels by biological membrane hybridization.Nature protocols · 2026Review
- Tailoring the Design of Dendritic Thermogels Through Carbosilane and Polyglycerol Crosslinkers.Pharmaceutics · 2026Article
- Review
- Polycaprolactone-Itaconic Acid Resins for Additive Manufacturing of Environmentally Degradable 3D and 4D Materials by Thiol-ene Photopolymerization.Macromolecules · 2025Article
- Dexamethasone Delivery via Amphiphilic, Low-swelling Hydrogels Treats Postoperative Inflammation in Cervical Spine Applications.Advanced healthcare materials · 2025Article
- Augmentation of Tendon and Ligament Repair with Fiber-Reinforced Hydrogel Composites.Advanced healthcare materials · 2024Review
- Hydrogel mechanical properties in altered gravity.NPJ microgravity · 2024Article
- Electroresponsive Thiol-Yne Click-Hydrogels for Insulin Smart Delivery: Tackling Sustained Release and Leakage Control.ACS applied polymer materials · 2024Article
- Metal-Free Click-Chemistry: A Powerful Tool for Fabricating Hydrogels for Biomedical Applications.Bioconjugate chemistry · 2024Review
- Fine-Tuning the Amphiphilic Properties of Carbosilane Dendritic Networks towards High-Swelling Thermogels.Pharmaceutics · 2024Article
- Bifunctional Carbosilane Dendrimers for the Design of Multipurpose Hydrogels with Antibacterial Action.Chemistry of materials : a publication of the American Chemical Society · 2024Article
- Tailoring the Swelling-Shrinkable Behavior of Hydrogels for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Self-Healing Hydrogel Scaffolds through PET-RAFT Polymerization in Cellular Environment.Biomacromolecules · 2023Article
- One-Step Soaking Strategy toward Anti-Swelling Hydrogels with a Stiff "Armor".Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Development and evaluation of RADA-PDGF2 self-assembling peptide hydrogel for enhanced skin wound healing.Frontiers in pharmacology · 2023Article
- Combined Effects of Radiative and Evaporative Cooling on Fruit Preservation under Solar Radiation: Sunburn Resistance and Temperature Stabilization.ACS applied materials & interfaces · 2022Article
- Click Step-Growth Polymerization andAccounts of chemical research · 2022Article
- Using Stereochemistry to Control Mechanical Properties in Thiol-Yne Click-Hydrogels.Angewandte Chemie (International ed. in English) · 2021Article
- Using Stereochemistry to Control Mechanical Properties in Thiol-Yne Click-Hydrogels.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2021Article
- 3D printing of sacrificial thioester elastomers using digital light processing for templating 3D organoid structures in soft biomatrices.Biofabrication · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A key drawback of hydrogel materials for tissue engineering applications is their characteristic swelling response, which leads to a diminished mechanical performance. However, if a solution can be found to overcome such limitations, there is a wider application for these materials. Herein, we describe a simple and effective way to control the swelling and degradation rate of nucleophilic thiol-yne poly(ethylene glycol) (PEG) hydrogel networks using two straightforward routes: (1) using multiarm alkyne and thiol terminated PEG precursors or (2) introducing a thermoresponsive unit into the PEG network while maintaining their robust mechanical properties. In situ hydrogel materials were formed in under 10 min in PBS solution at pH 7.4 without the need for an external catalyst by using easily accessible precursors. Both pathways resulted in strong tunable hydrogel materials (compressive strength values up to 2.4 MPa) which could effectively encapsulate cells, thus highlighting their potential as soft tissue scaffolds.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.