ReviewPharmaceutical biology2017
The genus Scrophularia: a source of iridoids and terpenoids with a diverse biological activity.
Review in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Chemical Profiling ofPlants (Basel, Switzerland) · 2025Article
- Phytochemical Profiling and Anti-Obesogenic Potential ofMolecules (Basel, Switzerland) · 2025Article
- Harnessing Plant Bioactive Compounds in Biomaterial Scaffolds for Advanced Wound Healing: A Comprehensive Review.Biomedicines · 2025Review
- Targeting Inflammation with Natural Products: A Mechanistic Review of Iridoids from Bulgarian Medicinal Plants.Molecules (Basel, Switzerland) · 2025Review
- Herbal Extract-Induced DNA Damage, Apoptosis, and Antioxidant Effects ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Exploring Naturally-Derived Targeted Nano Delivery Therapy for Burn Wound Healing with Special Emphasis on Preclinical Outcomes.Current drug delivery · 2025Review
- Study on the Neuroprotective Effects of Eight Iridoid Components Using Cell Metabolomics.Molecules (Basel, Switzerland) · 2024Article
- Comparative plastome analyses and evolutionary relationships of 25 East Asian species within the medicinal plant genusFrontiers in plant science · 2024Article
- Article
- Combined analysis of transcriptomics and metabolomics revealed complex metabolic genes for diterpenoids biosynthesis in different organs ofChinese herbal medicines · 2023Article
- Kampo herbal ointments for skin wound healing.Frontiers in pharmacology · 2023Review
- Chemometric-guided chemical marker selection: A case study of the heat-clearing herbFrontiers in plant science · 2023Article
- Ameliorative Effect of Aqueous and Hydroalcoholic Extracts ofAdvanced biomedical research · 2023Article
- Ethnopharmacobotany and Diversity of Mediterranean Endemic Plants in Marmilla Subregion, Sardinia, Italy.Plants (Basel, Switzerland) · 2022Article
- Gentians, natural remedies for future of visceral pain control; an ethnopharmacological review with an in silico approach.Biologia futura · 2022Review
- The Antimicrobial and Healing Effect ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Revisiting nature: a review of iridoids as a potential antileishmanial class.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2022Review
- Chemical Characterization and Anti-HIV-1 Activity Assessment of Iridoids and Flavonols fromMolecules (Basel, Switzerland) · 2021Article
- ThreePlants (Basel, Switzerland) · 2020Article
- Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextScrophularia genus (Scrophulariaceae) includes about 350 species commonly known as figwort. Many species of this genus grow wild in nature and have not been cultivated yet. However, some species are in danger of extinction.
objectiveThis paper reviews the chemical compounds, biological activities and the ethnopharmacology of some Scrophularia species. MATERIALS AND
methodsAll information was obtained through reported data on bibliographic database such as Scopus, United States National Agricultural Library, Biological Abstracts, EMBASE, PubMed, MedlinePlus, PubChem and Springer Link (1934-2017). The information in different Pharmacopoeias on this genus was also gathered from 1957 to 2007.
resultsThe structures of 204 compounds and their biological activity were presented in the manuscript: glycoside esters, iridoid glycosides and triterpenoids are the most common compounds in this genus. Among them, scropolioside like iridoids have shown potential for anti-inflammatory, hepatoprotective and wound healing activity. Among the less frequently isolated compounds, resin glycosides such as crypthophilic acids have shown potent antiprotozoal and antimicrobial activities.
conclusionThe Scrophularia genus seems to be a rich source of iridoids and terpenoids, but isolation and identification of its alkaloids have been a neglected area of scientific study. The diverse chemical compounds and biological activities of this genus will motivate further investigation on Scrophularia genus as a source of new therapeutic medications.
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