Evidence map›Paper›PMID 29124890›Full record

ReviewWiley interdisciplinary reviews. RNA2018

New perspectives on telomerase RNA structure and function.

Cherie Musgrove, Linnea I Jansson, Michael D Stone

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. RNA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Functional Interactions ofInternational journal of molecular sciences · 2022
    Article
  3. Single-Run Catalysis and Kinetic Control of Human Telomerase Holoenzyme.Advances in experimental medicine and biology · 2022
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Telomerase RNAs in land plants.Nucleic acids research · 2019
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cherie MusgroveDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA, USA.
Linnea I JanssonDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Cruz, CA, USA.
Michael D StoneDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA.
University of California, Santa Cruz · US

Funding

Structure and dynamics of the Tetrahymena telomerase ribonucleoproteinR01GM095850 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STONE, MICHAEL D · 2011 to 2023
$4.4M
Training Program/Molecular/Cell/Developmental BiologyT32GM008646 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STROME, SUSAN · 1999 to 2018
$3.7M
RNA and Protein function in TelomeraseF32GM075482 · NIGMS · HARVARD UNIVERSITY · PI STONE, MICHAEL D · 2005 to 2007
$118k
The roles of telomerase and non-coding RNA in cancerF99CA212439 · NCI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI JANSSON-FRITZBERG, LINNEA · 2016 to 2017
$73k
NCI NIH HHS F99 CA212439NIGMS NIH HHS F32 GM075482NIGMS NIH HHS R01 GM095850NIGMS NIH HHS T32 GM008646
6 · The paper itself

Abstract

Telomerase is an ancient ribonucleoprotein (RNP) that protects the ends of linear chromosomes from the loss of critical coding sequences through repetitive addition of short DNA sequences. These repeats comprise the telomere, which together with many accessory proteins, protect chromosomal ends from degradation and unwanted DNA repair. Telomerase is a unique reverse transcriptase (RT) that carries its own RNA to use as a template for repeat addition. Over decades of research, it has become clear that there are many diverse, crucial functions played by telomerase RNA beyond simply acting as a template. In this review, we highlight recent findings in three model systems: ciliates, yeast and vertebrates, that have shifted the way the field views the structural and mechanistic role(s) of RNA within the functional telomerase RNP complex. Viewed in this light, we hope to demonstrate that while telomerase RNA is just one example of the myriad functional RNA in the cell, insights into its structure and mechanism have wide-ranging impacts. WIREs RNA 2018, 9:e1456. doi: 10.1002/wrna.1456 This article is categorized under: RNA Structure and Dynamics > Influence of RNA Structure in Biological Systems RNA Structure and Dynamics > RNA Structure, Dynamics and Chemistry RNA Evolution and Genomics > RNA and Ribonucleoprotein Evolution.

Indexed as

RNATelomeraseAnimalsCiliophoraHumansNucleic Acid ConformationYeastsRNATelomerasetelomerase RNA

Identifiers

PMID29124890
PMCPMC5815921
OpenAlexW2767611854

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.