Evidence map›Paper›PMID 29124761›Full record

ArticleJournal of neurochemistry2018

Longitudinal investigation of neuroinflammation and metabolite profiles in the APP

Aisling Chaney, Martin Bauer, Daniela Bochicchio, Alison Smigova, Michael Kassiou, Karen E Davies, Steve R Williams, Herve Boutin

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Measurement of Protein Synthesis Rate in Rat by [Molecular imaging and biology · 2023
    Article
  6. Review
  7. TSPO imaging in animal models of brain diseases.European journal of nuclear medicine and molecular imaging · 2021
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Frontiers in neuroscience · 2021
    Article
  14. Review
  15. Fluorescence-activated cell sorting to reveal the cell origin of radioligand binding.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
  16. Review
  17. Article
  18. Molecular imaging and biology · 2019
    Article
  19. Review
  20. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Aisling ChaneyCentre for Imaging Science, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre University of Manchester, Manchester, UK.
Martin BauerDepartment of Clinical Pharmacology, Medical University Vienna, Vienna, Austria.
Daniela BochicchioWolfson Molecular Imaging Centre, Faculty of Biology, Medicine and Health and Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK.
Alison SmigovaCentre for Imaging Science, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre University of Manchester, Manchester, UK.
Michael KassiouSchool of Chemistry, University of Sydney, NSW, Australia.
Karen E DaviesCentre for Imaging Science, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre University of Manchester, Manchester, UK.
Steve R WilliamsCentre for Imaging Science, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre University of Manchester, Manchester, UK.ORCID 0000-0001-5940-1675
Herve BoutinCentre for Imaging Science, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre University of Manchester, Manchester, UK.ORCID 0000-0002-0029-5246
Manchester Academic Health Science Centre · GBMedical University of Vienna · ATThe University of Sydney · AU

Funding

Biotechnology and Biological Sciences Research Council BB/F011350/1
6 · The paper itself

Abstract

There is increasing evidence linking neuroinflammation to many neurological disorders including Alzheimer's disease (AD); however, its exact contribution to disease manifestation and/or progression is poorly understood. Therefore, there is a need to investigate neuroinflammation in both health and disease. Here, we investigate cognitive decline, neuroinflammatory and other pathophysiological changes in the APP

Indexed as

Disease Models, AnimalAlzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsBehavior, AnimalCerebral CortexCognitive DysfunctionEncephalitisHippocampusMagnetic Resonance SpectroscopyMaleMemoryMetabolomeMice, Inbred C57BLMice, TransgenicPositron-Emission TomographyAmyloid beta-Protein PrecursorPresenilin-1Alzheimer's diseaseanimal modelmagnetic resonance spectroscopyneuroinflammationpositron emission tomography

Identifiers

PMID29124761
PMCPMC5846890
OpenAlexW2767958421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.