ReviewClinical autonomic research : official journal of the Clinical Autonomic Research Society2018
Urological dysfunction in synucleinopathies: epidemiology, pathophysiology and management.
Review in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Therapeutic Applications of Botulinum Neurotoxin for Autonomic Symptoms in Parkinson's Disease: An Updated Review.Toxins · 2021Pooled it
- Clinical study of the effects of deep brain stimulation on urinary dysfunctions in patients with Parkinson's disease.Clinical interventions in aging · 2019Trial
- Urogenital dysfunction in neurological diseases.Nature reviews. Neurology · 2026Review
- An eight-year follow-up of the CMSAR: assessing how the new MDS criteria and biomarkers impact diagnostic accuracy.NPJ Parkinson's disease · 2026Article
- Video Urodynamic Study in Patients with Parkinson's Disease and Multiple System Atrophy.Movement disorders clinical practice · 2026Article
- Factors associated with orthostatic hypotension presence and severity in multiple system atrophy: a cross-sectional study.Frontiers in neurology · 2026Article
- Autonomic dysfunction in multiple system atrophy: from pathophysiology to clinical manifestations.Annals of medicine · 2025Review
- Voided Percentage Is More Useful Than Post-Void Residuals in Differentiating Multiple System Atrophy from Parkinson's Disease.Movement disorders clinical practice · 2025Article
- A simple and effective screening strategy for early multiple system atrophy diagnosis and α-Synuclein forms in erythrocytes.Frontiers in aging neuroscience · 2025Article
- Urinary continence networks in Parkinson's disease: a resting state functional MRI study.BJU international · 2025Article
- Review
- The examination of detrusor underactivity in multiple system atrophy.Frontiers in neurology · 2024Article
- Non-Pharmacological Treatment of Autonomic Dysfunction in Parkinson's Disease and Other Synucleinopathies.Journal of Parkinson's disease · 2024Review
- Symptomatic Care in Multiple System Atrophy: State of the Art.Cerebellum (London, England) · 2023Review
- Urodynamic Study in Multiple System Atrophy: A Retrospective Observational Study.Brain & NeuroRehabilitation · 2023Article
- How brain diseases affect the lower urinary tract function?Bladder (San Francisco, Calif.) · 2023Review
- Analysis of sleep, daytime sleepiness, and autonomic function in multiple system atrophy and Parkinson disease: a prospective study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Female Urinary Retention Progressing to Possible Multiple System Atrophy-cerebellar Form after 12 Years.Internal medicine (Tokyo, Japan) · 2022Article
- Lower urinary tract dysfunction in Parkinsonian syndromes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- Lower urinary tract and bowel dysfunction in spinocerebellar ataxias.Annals of clinical and translational neurology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveParkinson's disease (PD) and multiple system atrophy (MSA) are major neurogenerative diseases characterized pathologically by abnormal alpha-synuclein aggregation. PD and MSA are clinically characterized by motor disorder and bladder dysfunction (mainly urinary urgency and frequency, also called overactive bladder). However, few literatures are available concerning bladder dysfunction in PD or MSA.
methodA systematic review.
resultsThe bladder dysfunction in MSA is more severe than that in PD for large post-void residual or urinary retention. These bladder dysfunctions presumably reflect the different nervous system pathologies. Overactive bladder in PD reflects lesions in the brain, e.g., in the prefrontal-nigrostriatal D1 dopaminergic bladder-inhibitory pathway. Overactive bladder in MSA reflects lesions similar to PD and the cerebellum (bladder-inhibitory), and the urinary retention in MSA presumably reflects lesions in the pontine micturition center and the sacral intermediolateral nucleus of the spinal cord (bladder-facilitatory). Bladder dysfunction not only impairs an individual's quality of life, it can also cause emergency hospitalizations due to acute retention and early institutionalization. Anticholinergics are the first-line treatment for bladder dysfunction in PD and MSA patients, but care should be taken for the management of bladder dysfunction-particularly in MSA patients due to the high prevalence of difficult emptying, which needs clean, intermittent catheterization.
conclusionsThis review summarizes the epidemiology, pathophysiology, and management of bladder dysfunction in individuals with PD or MSA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.